Neuron‐specific specificity protein 4 bigenomically regulates the transcription of all mitochondria‐ and nucleus‐encoded cytochrome c oxidase subunit genes in neurons

Neurons are highly dependent on oxidative metabolism for their energy supply, and cytochrome c oxidase (COX) is a key energy‐generating enzyme in the mitochondria. A unique feature of COX is that it is one of only four proteins in mammalian cells that are bigenomically regulated. Of its thirteen sub...

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Veröffentlicht in:	Journal of neurochemistry 2013-11, Vol.127 (4), p.496-508
Hauptverfasser:	Johar, Kaid, Priya, Anusha, Dhar, Shilpa, Liu, Qiuli, Wong‐Riley, Margaret T. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cell Nucleus - genetics Cells, Cultured Chromatin cytochrome c oxidase depolarization DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Electron Transport Complex IV - genetics Electron Transport Complex IV - metabolism Female Gene Knockdown Techniques Genes Genome, Mitochondrial Genomics High Mobility Group Proteins - genetics High Mobility Group Proteins - metabolism Male Mice Mice, Inbred C57BL Mitochondria Neurons Neurons - metabolism Protein Binding Protein Subunits - genetics Protein Subunits - metabolism Sp4 Sp4 Transcription Factor - genetics Sp4 Transcription Factor - metabolism transcription factor Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic TTX Visual Cortex - cytology
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