Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

Many neurodegenerative diseases are characterized by the accumulation of insoluble protein aggregates, including neurofibrillary tangles comprised of tau in Alzheimer’s disease and Lewy bodies composed of α-synuclein in Parkinson’s disease. Moreover, different pathological proteins frequently codepo...

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Veröffentlicht in:	Cell 2013-07, Vol.154 (1), p.103-117
Hauptverfasser:	Guo, Jing L., Covell, Dustin J., Daniels, Joshua P., Iba, Michiyo, Stieber, Anna, Zhang, Bin, Riddle, Dawn M., Kwong, Linda K., Xu, Yan, Trojanowski, John Q., Lee, Virginia M.Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - chemistry alpha-Synuclein - metabolism Alzheimer disease Amyloid - chemistry Amyloid - metabolism Animals Cells, Cultured digestion Embryo, Mammalian - metabolism Humans Lewy bodies Male Mice Mice, Transgenic Neurons - metabolism Parkinson disease Parkinson Disease - metabolism Parkinson Disease - pathology peptidase K protein aggregates recombinant proteins Recombinant Proteins - metabolism tau Proteins - metabolism transgenic animals
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