Neuroprotective Effect of Ginkgolide B on Bupivacaine-Induced Apoptosis in SH-SY5Y Cells

Local anesthetics are used routinely and effectively. However, many are also known to activate neurotoxic pathways. We tested the neuroprotective efficacy of ginkgolide B (GB), an active component of Ginkgo biloba, against ROS-mediated neurotoxicity caused by the local anesthetic bupivacaine. SH-SY5...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2013-01, Vol.2013 (2013), p.1-11
Hauptverfasser:	Xu, Shi-yuan, Cheung, Chi-wai, Zheng, Ting, Zhou, Shu-qin, Wen, Xian-jie, Lai, Lu-ying, Li, Le, Zhang, Qing-guo
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Bupivacaine - toxicity Caspase 12 - genetics Caspase 12 - metabolism Caspase 3 - metabolism Cell Line, Tumor Cell Proliferation - drug effects Cell Shape - drug effects Cell Shape - genetics Cell Survival - drug effects Cell Survival - genetics Electron Transport Complex I - metabolism Electron Transport Complex III - metabolism Endoplasmic Reticulum Stress - drug effects Endoplasmic Reticulum Stress - genetics Enzyme Activation - drug effects Flow Cytometry Ginkgolides - pharmacology Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism High-Temperature Requirement A Serine Peptidase 2 Humans Lactones - pharmacology Membrane Potential, Mitochondrial - drug effects Membrane Potential, Mitochondrial - genetics Mitochondria - drug effects Mitochondria - metabolism Mitochondria - ultrastructure Mitochondrial Proteins - metabolism Neuroprotective Agents - pharmacology Reactive Oxygen Species - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Serine Endopeptidases - metabolism
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