Spontaneous Wheel Running Exercise Induces Brain Recovery via Neurotrophin-3 Expression Following Experimental Traumatic Brain Injury in Rats
[Purpose] The aim of the present study was to investigate the expression of neurotrophin-3 (NT-3) after applying spontaneous wheel running exercises (SWR) after experimental traumatic brain injury (TBI). [Subjects and Methods] Thirty male Sprague-Dawley rats were divided into 3 groups; 20 rats were...
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| Veröffentlicht in: | Journal of Physical Therapy Science 2013, Vol.25(9), pp.1103-1107 |
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| creator | Koo, Hyun Mo Lee, Sun Min Kim, Min Hee |
| description | [Purpose] The aim of the present study was to investigate the expression of neurotrophin-3 (NT-3) after applying spontaneous wheel running exercises (SWR) after experimental traumatic brain injury (TBI). [Subjects and Methods] Thirty male Sprague-Dawley rats were divided into 3 groups; 20 rats were subjected to controlled cortical impact for TBI, and then, animals were randomly collected from the SWR group and subjected to wheel running exercise for 3 weeks. Ten rats were not subjected to any injury or running exercise to compare with the effect of TBI and SWR. Immunohistochemistry, Western blotting, skilled ladder rung walking test, and 2,3,5-triphenyltetrazolium chloride staining analysis for the evaluation of NT-3 expression were used to assess brain damage and recovery. [Results] The TBI-induced decrease in NT-3 expression was recovered by wheel running exercise. Moreover, decreased ischemic volume and progressive neurobehavioral outcome were observed in the SWR group. [Conclusion] Spontaneous running exercise promotes brain recovery and motor function through an increase in expression of NT-3. |
| doi_str_mv | 10.1589/jpts.25.1103 |
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[Subjects and Methods] Thirty male Sprague-Dawley rats were divided into 3 groups; 20 rats were subjected to controlled cortical impact for TBI, and then, animals were randomly collected from the SWR group and subjected to wheel running exercise for 3 weeks. Ten rats were not subjected to any injury or running exercise to compare with the effect of TBI and SWR. Immunohistochemistry, Western blotting, skilled ladder rung walking test, and 2,3,5-triphenyltetrazolium chloride staining analysis for the evaluation of NT-3 expression were used to assess brain damage and recovery. [Results] The TBI-induced decrease in NT-3 expression was recovered by wheel running exercise. Moreover, decreased ischemic volume and progressive neurobehavioral outcome were observed in the SWR group. [Conclusion] Spontaneous running exercise promotes brain recovery and motor function through an increase in expression of NT-3.</description><identifier>ISSN: 0915-5287</identifier><identifier>EISSN: 2187-5626</identifier><identifier>DOI: 10.1589/jpts.25.1103</identifier><identifier>PMID: 24259924</identifier><language>eng</language><publisher>Japan: The Society of Physical Therapy Science</publisher><subject>Neurotrophin-3 ; Original ; Traumatic brain injury ; Wheel running exercise</subject><ispartof>Journal of Physical Therapy Science, 2013, Vol.25(9), pp.1103-1107</ispartof><rights>2013 by the Society of Physical Therapy Science</rights><rights>2013©by the Society of Physical Therapy Science 2013</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c763t-7a5a378e2afe6539a03fbb8385fd3d7a5bf4b817b9f908c3dbaf9aa204728e943</citedby><cites>FETCH-LOGICAL-c763t-7a5a378e2afe6539a03fbb8385fd3d7a5bf4b817b9f908c3dbaf9aa204728e943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818758/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818758/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1883,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24259924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koo, Hyun Mo</creatorcontrib><creatorcontrib>Lee, Sun Min</creatorcontrib><creatorcontrib>Kim, Min Hee</creatorcontrib><creatorcontrib>College of Health Science</creatorcontrib><creatorcontrib>Department of Physical Therapy</creatorcontrib><creatorcontrib>Dongju University</creatorcontrib><creatorcontrib>College of Science</creatorcontrib><creatorcontrib>Kyungsung University</creatorcontrib><creatorcontrib>Department of Occupational Therapy</creatorcontrib><creatorcontrib>Eulji University</creatorcontrib><title>Spontaneous Wheel Running Exercise Induces Brain Recovery via Neurotrophin-3 Expression Following Experimental Traumatic Brain Injury in Rats</title><title>Journal of Physical Therapy Science</title><addtitle>Journal of Physical Therapy Science</addtitle><description>[Purpose] The aim of the present study was to investigate the expression of neurotrophin-3 (NT-3) after applying spontaneous wheel running exercises (SWR) after experimental traumatic brain injury (TBI). [Subjects and Methods] Thirty male Sprague-Dawley rats were divided into 3 groups; 20 rats were subjected to controlled cortical impact for TBI, and then, animals were randomly collected from the SWR group and subjected to wheel running exercise for 3 weeks. Ten rats were not subjected to any injury or running exercise to compare with the effect of TBI and SWR. Immunohistochemistry, Western blotting, skilled ladder rung walking test, and 2,3,5-triphenyltetrazolium chloride staining analysis for the evaluation of NT-3 expression were used to assess brain damage and recovery. [Results] The TBI-induced decrease in NT-3 expression was recovered by wheel running exercise. Moreover, decreased ischemic volume and progressive neurobehavioral outcome were observed in the SWR group. [Conclusion] Spontaneous running exercise promotes brain recovery and motor function through an increase in expression of NT-3.</description><subject>Neurotrophin-3</subject><subject>Original</subject><subject>Traumatic brain injury</subject><subject>Wheel running exercise</subject><issn>0915-5287</issn><issn>2187-5626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkktv1DAUhSMEotPCjjXKkgUZ_IgTe4MEVR8jVSCVIpaW47mZceSxg50M9Ef0P-M0w6is2NiS7_F3j-9xlr3BaIkZFx-6fohLwpYYI_osWxDM64JVpHqeLZDArGCE1yfZaYwdQqRGJX-ZnZCSMCFIucgevvXeDcqBH2P-Ywtg89vROeM2-cVvCNpEyFduPWqI-eegjMtvQfs9hPt8b1T-Bcbgh-D7rXEFTVf6ADEa7_JLb63_NXN6CGYHqY3N74Iad2ow-kBbuW5MrImrhvgqe9EqG-H1YT_Lvl9e3J1fFzdfr1bnn24KXVd0KGrFFK05ENVCxahQiLZNwyln7ZquU7Vpy4bjuhGtQFzTdaNaoRRBZU04iJKeZR9nbj82O1jr5C0oK_tkU4V76ZWR_1ac2cqN30vK03gZT4B3B0DwP0eIg9yZqMHaeZISM1pygmiF_y8tK0FQzR9tvZ-lOvgYA7RHRxjJKWw5hS0Jk1PYSf726SuO4r_pJsHVLEhVo5X1zhoHsvNjcGm8UivezUSEqUzfgyEhESaP-GmpCS7TMUqk65nUxUFt4NhKhRSlhaMvMS1PkAIfJXqrggRH_wDIsNqA</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Koo, Hyun Mo</creator><creator>Lee, Sun Min</creator><creator>Kim, Min Hee</creator><general>The Society of Physical Therapy Science</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TS</scope><scope>5PM</scope></search><sort><creationdate>2013</creationdate><title>Spontaneous Wheel Running Exercise Induces Brain Recovery via Neurotrophin-3 Expression Following Experimental Traumatic Brain Injury in Rats</title><author>Koo, Hyun Mo ; Lee, Sun Min ; Kim, Min Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c763t-7a5a378e2afe6539a03fbb8385fd3d7a5bf4b817b9f908c3dbaf9aa204728e943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Neurotrophin-3</topic><topic>Original</topic><topic>Traumatic brain injury</topic><topic>Wheel running exercise</topic><toplevel>online_resources</toplevel><creatorcontrib>Koo, Hyun Mo</creatorcontrib><creatorcontrib>Lee, Sun Min</creatorcontrib><creatorcontrib>Kim, Min Hee</creatorcontrib><creatorcontrib>College of Health Science</creatorcontrib><creatorcontrib>Department of Physical Therapy</creatorcontrib><creatorcontrib>Dongju University</creatorcontrib><creatorcontrib>College of Science</creatorcontrib><creatorcontrib>Kyungsung University</creatorcontrib><creatorcontrib>Department of Occupational Therapy</creatorcontrib><creatorcontrib>Eulji University</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Physical Therapy Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koo, Hyun Mo</au><au>Lee, Sun Min</au><au>Kim, Min Hee</au><aucorp>College of Health Science</aucorp><aucorp>Department of Physical Therapy</aucorp><aucorp>Dongju University</aucorp><aucorp>College of Science</aucorp><aucorp>Kyungsung University</aucorp><aucorp>Department of Occupational Therapy</aucorp><aucorp>Eulji University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous Wheel Running Exercise Induces Brain Recovery via Neurotrophin-3 Expression Following Experimental Traumatic Brain Injury in Rats</atitle><jtitle>Journal of Physical Therapy Science</jtitle><addtitle>Journal of Physical Therapy Science</addtitle><date>2013</date><risdate>2013</risdate><volume>25</volume><issue>9</issue><spage>1103</spage><epage>1107</epage><pages>1103-1107</pages><issn>0915-5287</issn><eissn>2187-5626</eissn><abstract>[Purpose] The aim of the present study was to investigate the expression of neurotrophin-3 (NT-3) after applying spontaneous wheel running exercises (SWR) after experimental traumatic brain injury (TBI). [Subjects and Methods] Thirty male Sprague-Dawley rats were divided into 3 groups; 20 rats were subjected to controlled cortical impact for TBI, and then, animals were randomly collected from the SWR group and subjected to wheel running exercise for 3 weeks. Ten rats were not subjected to any injury or running exercise to compare with the effect of TBI and SWR. Immunohistochemistry, Western blotting, skilled ladder rung walking test, and 2,3,5-triphenyltetrazolium chloride staining analysis for the evaluation of NT-3 expression were used to assess brain damage and recovery. [Results] The TBI-induced decrease in NT-3 expression was recovered by wheel running exercise. Moreover, decreased ischemic volume and progressive neurobehavioral outcome were observed in the SWR group. [Conclusion] Spontaneous running exercise promotes brain recovery and motor function through an increase in expression of NT-3.</abstract><cop>Japan</cop><pub>The Society of Physical Therapy Science</pub><pmid>24259924</pmid><doi>10.1589/jpts.25.1103</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Neurotrophin-3 Original Traumatic brain injury Wheel running exercise |
| title | Spontaneous Wheel Running Exercise Induces Brain Recovery via Neurotrophin-3 Expression Following Experimental Traumatic Brain Injury in Rats |
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