Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology

Regular use of aspirin reduces incidence and mortality of various cancers, including colorectal cancer. Anticancer effect of aspirin represents one of the ‘Provocative Questions’ in cancer research. Experimental and clinical studies support a carcinogenic role for PTGS2 (cyclooxygenase-2), which is...

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Veröffentlicht in:	Oncogene 2014-06, Vol.33 (23), p.2949-2955
Hauptverfasser:	Ogino, S, Lochhead, P, Giovannucci, E, Meyerhardt, J A, Fuchs, C S, Chan, A T
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 631/208/737 692/53/2423 692/699/67/1504/1885 692/700/478/174 AKT protein Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Aspirin Aspirin - pharmacology Aspirin - therapeutic use Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Brain tumors Breast cancer Cancer Cancer research Cardiovascular diseases Cecum Cell Biology Class I Phosphatidylinositol 3-Kinases Colon cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics CpG islands Cyclooxygenase-2 Diabetes mellitus Disease DNA methylation Epidemiology Gene Expression Regulation Gene mutations Genetic aspects Genetic markers Genetic research Health aspects Health care Hepatocellular carcinoma Human Genetics Humans Identification and classification Inflammation Internal Medicine Intestinal microflora Kinases Lung cancer Lung carcinoma Medical research Medicine Medicine & Public Health Metabolic disorders Molecular biology Molecular Epidemiology - methods Mutation Oncology Oncology, Experimental Pathology Pathology, Molecular Phosphatidylinositol 3-Kinases - genetics Population Population studies Population-based studies Prognosis review Signal transduction Signal Transduction - drug effects Translational Medical Research
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