Carotenoids as possible interphotoreceptor retinoid-binding protein (IRBP) ligands: A surface plasmon resonance (SPR) based study

•Interphotoreceptor retinoid-binding protein (IRBP) binds a variety of ligands.•A surface plasmon resonance biosensor was employed to study these interactions.•IRBP is able to bind carotenoids and retinoids with similar affinities.•IRBP has 10times less affinity for ocular fatty acids.•IRBP may func...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2013-11, Vol.539 (2), p.181-186
Hauptverfasser:	Vachali, Preejith P., Besch, Brian M., Gonzalez-Fernandez, Federico, Bernstein, Paul S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals binding sites Biosensing Techniques - methods biosensors Carotenoids Carotenoids - chemistry Carotenoids - metabolism Cattle epithelium Eye Proteins - chemistry Eye Proteins - metabolism fatty acids Fatty Acids, Nonesterified - chemistry Fatty Acids, Nonesterified - metabolism Humans Interphotoreceptor matrix Interphotoreceptor retinoid-binding protein Ligands lutein Macular pigments nutrients photoreceptors Protein Binding - physiology retina Retinoids Retinol-Binding Proteins - chemistry Retinol-Binding Proteins - metabolism Surface plasmon resonance Surface Plasmon Resonance - methods zeaxanthin
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