Fetal adrenal capsular cells serve as progenitor cells for steroidogenic and stromal adrenocortical cell lineages in M. musculus
The lineage relationships of fetal adrenal cells and adrenal capsular cells to the differentiated adrenal cortex are not fully understood. Existing data support a role for each cell type as a progenitor for cells of the adult cortex. This report reveals that subsets of capsular cells are descendants...
Gespeichert in:
Veröffentlicht in: | Development (Cambridge) 2013-11, Vol.140 (22), p.4522-4532 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 4532 |
---|---|
container_issue | 22 |
container_start_page | 4522 |
container_title | Development (Cambridge) |
container_volume | 140 |
creator | Wood, Michelle A Acharya, Asha Finco, Isabella Swonger, Jessica M Elston, Marlee J Tallquist, Michelle D Hammer, Gary D |
description | The lineage relationships of fetal adrenal cells and adrenal capsular cells to the differentiated adrenal cortex are not fully understood. Existing data support a role for each cell type as a progenitor for cells of the adult cortex. This report reveals that subsets of capsular cells are descendants of fetal adrenocortical cells that once expressed Nr5a1. These fetal adrenocortical cell descendants within the adrenal capsule express Gli1, a known marker of progenitors of steroidogenic adrenal cells. The capsule is also populated by cells that express Tcf21, a known inhibitor of Nr5a1 gene expression. We demonstrate that Tcf21-expressing cells give rise to Nr5a1-expressing cells but only before capsular formation. After the capsule has formed, capsular Tcf21-expressing cells give rise only to non-steroidogenic stromal adrenocortical cells, which also express collagen 1a1, desmin and platelet-derived growth factor (alpha polypeptide) but not Nr5a1. These observations integrate prior observations that define two separate origins of adult adrenocortical steroidogenic cells (fetal adrenal cortex and/or the adrenal capsule). Thus, these observations predict a unique temporal and/or spatial role of adult cortical cells that arise directly from either fetal cortical cells or from fetal cortex-derived capsular cells. Last, the data uncover the mechanism by which two populations of fetal cells (fetal cortex derived Gli1-expressing cells and mesenchymal Tcf21-expressing mesenchymal cells) participate in the establishment of the homeostatic capsular progenitor cell niche of the adult cortex. |
doi_str_mv | 10.1242/dev.092775 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3817941</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1551636118</sourcerecordid><originalsourceid>FETCH-LOGICAL-c477t-f6d26c61ea2b7325abb7a2489c2657c0781f586ca183c6f7610c6501d94ae29c3</originalsourceid><addsrcrecordid>eNqFkUFv1DAQhS1ERZeFCz8A-YiQsvXYiR1fkFBFAalVL3C2Zp3JYpTEi52sxI2fjpftVnDiNJbf56d5foy9ArEBWcurjg4bYaUxzRO2gtqYyoK0T9lK2EZUYC1csuc5fxdCKG3MM3Ypa1CgZbtiv25oxoFjl2gq0-M-LwMm7mkYMs-UDsQx832KO5rCHM9KX055phRD90fxHKeu3KQ4nu2ij2kO_uhanvAhTIQ7yjxM_G7DxyX7ZVjyC3bR45Dp5cNcs683H75cf6pu7z9-vn5_W_kSaK563UntNRDKrVGywe3WoKxb66VujBemhb5ptUdolde90SC8bgR0tkaS1qs1e3fy3S_bkTpP05xwcPsURkw_XcTg_lWm8M3t4sGpFowt_7Vmbx4MUvyxUJ7dGPIxGU4Ul-ygaUArDWWB_6J1XerSrVIFfXtCfYo5J-ofNwLhju260q47tVvg139neETPdarfpoWi7A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1449276833</pqid></control><display><type>article</type><title>Fetal adrenal capsular cells serve as progenitor cells for steroidogenic and stromal adrenocortical cell lineages in M. musculus</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>Company of Biologists</source><creator>Wood, Michelle A ; Acharya, Asha ; Finco, Isabella ; Swonger, Jessica M ; Elston, Marlee J ; Tallquist, Michelle D ; Hammer, Gary D</creator><creatorcontrib>Wood, Michelle A ; Acharya, Asha ; Finco, Isabella ; Swonger, Jessica M ; Elston, Marlee J ; Tallquist, Michelle D ; Hammer, Gary D</creatorcontrib><description>The lineage relationships of fetal adrenal cells and adrenal capsular cells to the differentiated adrenal cortex are not fully understood. Existing data support a role for each cell type as a progenitor for cells of the adult cortex. This report reveals that subsets of capsular cells are descendants of fetal adrenocortical cells that once expressed Nr5a1. These fetal adrenocortical cell descendants within the adrenal capsule express Gli1, a known marker of progenitors of steroidogenic adrenal cells. The capsule is also populated by cells that express Tcf21, a known inhibitor of Nr5a1 gene expression. We demonstrate that Tcf21-expressing cells give rise to Nr5a1-expressing cells but only before capsular formation. After the capsule has formed, capsular Tcf21-expressing cells give rise only to non-steroidogenic stromal adrenocortical cells, which also express collagen 1a1, desmin and platelet-derived growth factor (alpha polypeptide) but not Nr5a1. These observations integrate prior observations that define two separate origins of adult adrenocortical steroidogenic cells (fetal adrenal cortex and/or the adrenal capsule). Thus, these observations predict a unique temporal and/or spatial role of adult cortical cells that arise directly from either fetal cortical cells or from fetal cortex-derived capsular cells. Last, the data uncover the mechanism by which two populations of fetal cells (fetal cortex derived Gli1-expressing cells and mesenchymal Tcf21-expressing mesenchymal cells) participate in the establishment of the homeostatic capsular progenitor cell niche of the adult cortex.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.092775</identifier><identifier>PMID: 24131628</identifier><language>eng</language><publisher>England: Company of Biologists</publisher><subject>Adrenal Cortex - cytology ; Adrenal Cortex - embryology ; Aging - metabolism ; Animals ; Basic Helix-Loop-Helix Transcription Factors - metabolism ; Cell Lineage ; Fetus - cytology ; Homeostasis ; Mice ; Models, Biological ; Musculus ; Stem Cells - cytology ; Stem Cells and Regeneration ; Steroidogenic Factor 1 - metabolism ; Steroids - metabolism ; Stromal Cells ; Transcription Factors - metabolism ; Zinc Finger Protein GLI1</subject><ispartof>Development (Cambridge), 2013-11, Vol.140 (22), p.4522-4532</ispartof><rights>2013. Published by The Company of Biologists Ltd 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-f6d26c61ea2b7325abb7a2489c2657c0781f586ca183c6f7610c6501d94ae29c3</citedby><cites>FETCH-LOGICAL-c477t-f6d26c61ea2b7325abb7a2489c2657c0781f586ca183c6f7610c6501d94ae29c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3678,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24131628$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wood, Michelle A</creatorcontrib><creatorcontrib>Acharya, Asha</creatorcontrib><creatorcontrib>Finco, Isabella</creatorcontrib><creatorcontrib>Swonger, Jessica M</creatorcontrib><creatorcontrib>Elston, Marlee J</creatorcontrib><creatorcontrib>Tallquist, Michelle D</creatorcontrib><creatorcontrib>Hammer, Gary D</creatorcontrib><title>Fetal adrenal capsular cells serve as progenitor cells for steroidogenic and stromal adrenocortical cell lineages in M. musculus</title><title>Development (Cambridge)</title><addtitle>Development</addtitle><description>The lineage relationships of fetal adrenal cells and adrenal capsular cells to the differentiated adrenal cortex are not fully understood. Existing data support a role for each cell type as a progenitor for cells of the adult cortex. This report reveals that subsets of capsular cells are descendants of fetal adrenocortical cells that once expressed Nr5a1. These fetal adrenocortical cell descendants within the adrenal capsule express Gli1, a known marker of progenitors of steroidogenic adrenal cells. The capsule is also populated by cells that express Tcf21, a known inhibitor of Nr5a1 gene expression. We demonstrate that Tcf21-expressing cells give rise to Nr5a1-expressing cells but only before capsular formation. After the capsule has formed, capsular Tcf21-expressing cells give rise only to non-steroidogenic stromal adrenocortical cells, which also express collagen 1a1, desmin and platelet-derived growth factor (alpha polypeptide) but not Nr5a1. These observations integrate prior observations that define two separate origins of adult adrenocortical steroidogenic cells (fetal adrenal cortex and/or the adrenal capsule). Thus, these observations predict a unique temporal and/or spatial role of adult cortical cells that arise directly from either fetal cortical cells or from fetal cortex-derived capsular cells. Last, the data uncover the mechanism by which two populations of fetal cells (fetal cortex derived Gli1-expressing cells and mesenchymal Tcf21-expressing mesenchymal cells) participate in the establishment of the homeostatic capsular progenitor cell niche of the adult cortex.</description><subject>Adrenal Cortex - cytology</subject><subject>Adrenal Cortex - embryology</subject><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Basic Helix-Loop-Helix Transcription Factors - metabolism</subject><subject>Cell Lineage</subject><subject>Fetus - cytology</subject><subject>Homeostasis</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Musculus</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells and Regeneration</subject><subject>Steroidogenic Factor 1 - metabolism</subject><subject>Steroids - metabolism</subject><subject>Stromal Cells</subject><subject>Transcription Factors - metabolism</subject><subject>Zinc Finger Protein GLI1</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS1ERZeFCz8A-YiQsvXYiR1fkFBFAalVL3C2Zp3JYpTEi52sxI2fjpftVnDiNJbf56d5foy9ArEBWcurjg4bYaUxzRO2gtqYyoK0T9lK2EZUYC1csuc5fxdCKG3MM3Ypa1CgZbtiv25oxoFjl2gq0-M-LwMm7mkYMs-UDsQx832KO5rCHM9KX055phRD90fxHKeu3KQ4nu2ij2kO_uhanvAhTIQ7yjxM_G7DxyX7ZVjyC3bR45Dp5cNcs683H75cf6pu7z9-vn5_W_kSaK563UntNRDKrVGywe3WoKxb66VujBemhb5ptUdolde90SC8bgR0tkaS1qs1e3fy3S_bkTpP05xwcPsURkw_XcTg_lWm8M3t4sGpFowt_7Vmbx4MUvyxUJ7dGPIxGU4Ul-ygaUArDWWB_6J1XerSrVIFfXtCfYo5J-ofNwLhju260q47tVvg139neETPdarfpoWi7A</recordid><startdate>20131115</startdate><enddate>20131115</enddate><creator>Wood, Michelle A</creator><creator>Acharya, Asha</creator><creator>Finco, Isabella</creator><creator>Swonger, Jessica M</creator><creator>Elston, Marlee J</creator><creator>Tallquist, Michelle D</creator><creator>Hammer, Gary D</creator><general>Company of Biologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20131115</creationdate><title>Fetal adrenal capsular cells serve as progenitor cells for steroidogenic and stromal adrenocortical cell lineages in M. musculus</title><author>Wood, Michelle A ; Acharya, Asha ; Finco, Isabella ; Swonger, Jessica M ; Elston, Marlee J ; Tallquist, Michelle D ; Hammer, Gary D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-f6d26c61ea2b7325abb7a2489c2657c0781f586ca183c6f7610c6501d94ae29c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adrenal Cortex - cytology</topic><topic>Adrenal Cortex - embryology</topic><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Basic Helix-Loop-Helix Transcription Factors - metabolism</topic><topic>Cell Lineage</topic><topic>Fetus - cytology</topic><topic>Homeostasis</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>Musculus</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells and Regeneration</topic><topic>Steroidogenic Factor 1 - metabolism</topic><topic>Steroids - metabolism</topic><topic>Stromal Cells</topic><topic>Transcription Factors - metabolism</topic><topic>Zinc Finger Protein GLI1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wood, Michelle A</creatorcontrib><creatorcontrib>Acharya, Asha</creatorcontrib><creatorcontrib>Finco, Isabella</creatorcontrib><creatorcontrib>Swonger, Jessica M</creatorcontrib><creatorcontrib>Elston, Marlee J</creatorcontrib><creatorcontrib>Tallquist, Michelle D</creatorcontrib><creatorcontrib>Hammer, Gary D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wood, Michelle A</au><au>Acharya, Asha</au><au>Finco, Isabella</au><au>Swonger, Jessica M</au><au>Elston, Marlee J</au><au>Tallquist, Michelle D</au><au>Hammer, Gary D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetal adrenal capsular cells serve as progenitor cells for steroidogenic and stromal adrenocortical cell lineages in M. musculus</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>2013-11-15</date><risdate>2013</risdate><volume>140</volume><issue>22</issue><spage>4522</spage><epage>4532</epage><pages>4522-4532</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>The lineage relationships of fetal adrenal cells and adrenal capsular cells to the differentiated adrenal cortex are not fully understood. Existing data support a role for each cell type as a progenitor for cells of the adult cortex. This report reveals that subsets of capsular cells are descendants of fetal adrenocortical cells that once expressed Nr5a1. These fetal adrenocortical cell descendants within the adrenal capsule express Gli1, a known marker of progenitors of steroidogenic adrenal cells. The capsule is also populated by cells that express Tcf21, a known inhibitor of Nr5a1 gene expression. We demonstrate that Tcf21-expressing cells give rise to Nr5a1-expressing cells but only before capsular formation. After the capsule has formed, capsular Tcf21-expressing cells give rise only to non-steroidogenic stromal adrenocortical cells, which also express collagen 1a1, desmin and platelet-derived growth factor (alpha polypeptide) but not Nr5a1. These observations integrate prior observations that define two separate origins of adult adrenocortical steroidogenic cells (fetal adrenal cortex and/or the adrenal capsule). Thus, these observations predict a unique temporal and/or spatial role of adult cortical cells that arise directly from either fetal cortical cells or from fetal cortex-derived capsular cells. Last, the data uncover the mechanism by which two populations of fetal cells (fetal cortex derived Gli1-expressing cells and mesenchymal Tcf21-expressing mesenchymal cells) participate in the establishment of the homeostatic capsular progenitor cell niche of the adult cortex.</abstract><cop>England</cop><pub>Company of Biologists</pub><pmid>24131628</pmid><doi>10.1242/dev.092775</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0950-1991 |
ispartof | Development (Cambridge), 2013-11, Vol.140 (22), p.4522-4532 |
issn | 0950-1991 1477-9129 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3817941 |
source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Company of Biologists |
subjects | Adrenal Cortex - cytology Adrenal Cortex - embryology Aging - metabolism Animals Basic Helix-Loop-Helix Transcription Factors - metabolism Cell Lineage Fetus - cytology Homeostasis Mice Models, Biological Musculus Stem Cells - cytology Stem Cells and Regeneration Steroidogenic Factor 1 - metabolism Steroids - metabolism Stromal Cells Transcription Factors - metabolism Zinc Finger Protein GLI1 |
title | Fetal adrenal capsular cells serve as progenitor cells for steroidogenic and stromal adrenocortical cell lineages in M. musculus |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T22%3A29%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fetal%20adrenal%20capsular%20cells%20serve%20as%20progenitor%20cells%20for%20steroidogenic%20and%20stromal%20adrenocortical%20cell%20lineages%20in%20M.%20musculus&rft.jtitle=Development%20(Cambridge)&rft.au=Wood,%20Michelle%20A&rft.date=2013-11-15&rft.volume=140&rft.issue=22&rft.spage=4522&rft.epage=4532&rft.pages=4522-4532&rft.issn=0950-1991&rft.eissn=1477-9129&rft_id=info:doi/10.1242/dev.092775&rft_dat=%3Cproquest_pubme%3E1551636118%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1449276833&rft_id=info:pmid/24131628&rfr_iscdi=true |