Neutrophil Gelatinase-Associated Lipocalin: Its Response to Hypoxia and Association with Acute Mountain Sickness
Acute Mountain Sickness (AMS) is a common clinical challenge at high altitude (HA). A point-of-care biochemical marker for AMS could have widespread utility. Neutrophil gelatinase-associated lipocalin (NGAL) rises in response to renal injury, inflammation and oxidative stress. We investigated whethe...
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| Veröffentlicht in: | Disease markers 2013-01, Vol.2013 (2013), p.1-6 |
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| creator | King, Rod Turner, Steve Woods, David R. Piper, Rick Yarker, Jo Begley, Joe Smith, Chris Hooper, Tim Stacey, Mike Boos, Christopher Mellor, Adrian O'Hara, John |
| description | Acute Mountain Sickness (AMS) is a common clinical challenge at high altitude (HA). A point-of-care biochemical marker for AMS could have widespread utility. Neutrophil gelatinase-associated lipocalin (NGAL) rises in response to renal injury, inflammation and oxidative stress. We investigated whether NGAL rises with HA and if this rise was related to AMS, hypoxia or exercise. NGAL was assayed in a cohort (n=22) undertaking 6 hours exercise at near sea-level (SL); a cohort (n=14) during 3 hours of normobaric hypoxia (FiO2 11.6%) and on two trekking expeditions (n=52) to over 5000 m. NGAL did not change with exercise at SL or following normobaric hypoxia. During the trekking expeditions NGAL levels (ng/ml, mean ± sd, range) rose significantly (P |
| doi_str_mv | 10.1155/2013/601214 |
| format | Article |
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A point-of-care biochemical marker for AMS could have widespread utility. Neutrophil gelatinase-associated lipocalin (NGAL) rises in response to renal injury, inflammation and oxidative stress. We investigated whether NGAL rises with HA and if this rise was related to AMS, hypoxia or exercise. NGAL was assayed in a cohort (n=22) undertaking 6 hours exercise at near sea-level (SL); a cohort (n=14) during 3 hours of normobaric hypoxia (FiO2 11.6%) and on two trekking expeditions (n=52) to over 5000 m. NGAL did not change with exercise at SL or following normobaric hypoxia. During the trekking expeditions NGAL levels (ng/ml, mean ± sd, range) rose significantly (P<0.001) from 68 ± 14 (60–102) at 1300 m to 183 ± 107 (65–519); 143 ± 66 (60–315) and 150 ± 71 (60–357) at 3400 m, 4270 m and 5150 m respectively. At 5150 m there was a significant difference in NGAL between those with severe AMS (n=7), mild AMS (n=16) or no AMS (n=23): 201 ± 34 versus 171 ± 19 versus 124 ± 12 respectively (P=0.009 for severe versus no AMS; P=0.026 for mild versus no AMS). In summary, NGAL rises in response to prolonged hypobaric hypoxia and demonstrates a relationship to the presence and severity of AMS.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2013/601214</identifier><identifier>PMID: 24227892</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acute-Phase Proteins ; Adult ; Altitude ; Altitude Sickness - blood ; Altitude Sickness - diagnosis ; Biomarkers - blood ; Case-Control Studies ; Clinical Study ; Exercise ; Female ; Humans ; Hypoxia - blood ; Lipocalin-2 ; Lipocalins - blood ; Male ; Proto-Oncogene Proteins - blood</subject><ispartof>Disease markers, 2013-01, Vol.2013 (2013), p.1-6</ispartof><rights>Copyright © 2013 Adrian Mellor et al.</rights><rights>Copyright © 2013 Adrian Mellor et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-3330cd8e5a2da40d8fe1598cc6284523140aea511e2d1790837932ed575454fe3</citedby><cites>FETCH-LOGICAL-c439t-3330cd8e5a2da40d8fe1598cc6284523140aea511e2d1790837932ed575454fe3</cites><orcidid>0000-0002-4971-3939 ; 0000-0002-9061-5177</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817649/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817649/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24227892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lapaire, Olav</contributor><creatorcontrib>King, Rod</creatorcontrib><creatorcontrib>Turner, Steve</creatorcontrib><creatorcontrib>Woods, David R.</creatorcontrib><creatorcontrib>Piper, Rick</creatorcontrib><creatorcontrib>Yarker, Jo</creatorcontrib><creatorcontrib>Begley, Joe</creatorcontrib><creatorcontrib>Smith, Chris</creatorcontrib><creatorcontrib>Hooper, Tim</creatorcontrib><creatorcontrib>Stacey, Mike</creatorcontrib><creatorcontrib>Boos, Christopher</creatorcontrib><creatorcontrib>Mellor, Adrian</creatorcontrib><creatorcontrib>O'Hara, John</creatorcontrib><title>Neutrophil Gelatinase-Associated Lipocalin: Its Response to Hypoxia and Association with Acute Mountain Sickness</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Acute Mountain Sickness (AMS) is a common clinical challenge at high altitude (HA). A point-of-care biochemical marker for AMS could have widespread utility. Neutrophil gelatinase-associated lipocalin (NGAL) rises in response to renal injury, inflammation and oxidative stress. We investigated whether NGAL rises with HA and if this rise was related to AMS, hypoxia or exercise. NGAL was assayed in a cohort (n=22) undertaking 6 hours exercise at near sea-level (SL); a cohort (n=14) during 3 hours of normobaric hypoxia (FiO2 11.6%) and on two trekking expeditions (n=52) to over 5000 m. NGAL did not change with exercise at SL or following normobaric hypoxia. During the trekking expeditions NGAL levels (ng/ml, mean ± sd, range) rose significantly (P<0.001) from 68 ± 14 (60–102) at 1300 m to 183 ± 107 (65–519); 143 ± 66 (60–315) and 150 ± 71 (60–357) at 3400 m, 4270 m and 5150 m respectively. At 5150 m there was a significant difference in NGAL between those with severe AMS (n=7), mild AMS (n=16) or no AMS (n=23): 201 ± 34 versus 171 ± 19 versus 124 ± 12 respectively (P=0.009 for severe versus no AMS; P=0.026 for mild versus no AMS). In summary, NGAL rises in response to prolonged hypobaric hypoxia and demonstrates a relationship to the presence and severity of AMS.</description><subject>Acute-Phase Proteins</subject><subject>Adult</subject><subject>Altitude</subject><subject>Altitude Sickness - blood</subject><subject>Altitude Sickness - diagnosis</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Clinical Study</subject><subject>Exercise</subject><subject>Female</subject><subject>Humans</subject><subject>Hypoxia - blood</subject><subject>Lipocalin-2</subject><subject>Lipocalins - blood</subject><subject>Male</subject><subject>Proto-Oncogene Proteins - blood</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqN0U1v1DAQBmALgei2cOKOfESgUH8mNgekVQVtpQUkPs7WYE9YQ9YOsUPbf0-qbaty4-TDPPOOpZeQZ5y95lzrY8G4PG4ZF1w9ICtuOt2YVrKHZMVEZxomFDsgh6X8ZIuxyj4mB0KJZWTFiowfca5THrdxoKc4QI0JCjbrUrKPUDHQTRyzhyGmN_S8FvoZy5hTQVozPbsa82UECinQ242YE72IdUvXfq5IP-Q5VYiJfon-V8JSnpBHPQwFn968R-Tb-3dfT86azafT85P1pvFK2tpIKZkPBjWIAIoF0yPX1njfCqO0kFwxQNCcowi8s8zIzkqBQXdaadWjPCJv97nj_H2HwWOqEwxunOIOpiuXIbp_Jylu3Y_8x0nDu1bZJeDFTcCUf89YqtvF4nEYIGGei-NKW94yxdlCX-2pn3IpE_Z3Zzhz1x25647cvqNFP7__szt7W8oCXu7BNqYAF_H_0nAh2MM9LBfA5F8bcqQ2</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>King, Rod</creator><creator>Turner, Steve</creator><creator>Woods, David R.</creator><creator>Piper, Rick</creator><creator>Yarker, Jo</creator><creator>Begley, Joe</creator><creator>Smith, Chris</creator><creator>Hooper, Tim</creator><creator>Stacey, Mike</creator><creator>Boos, Christopher</creator><creator>Mellor, Adrian</creator><creator>O'Hara, John</creator><general>Hindawi Publishing Corporation</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4971-3939</orcidid><orcidid>https://orcid.org/0000-0002-9061-5177</orcidid></search><sort><creationdate>20130101</creationdate><title>Neutrophil Gelatinase-Associated Lipocalin: Its Response to Hypoxia and Association with Acute Mountain Sickness</title><author>King, Rod ; Turner, Steve ; Woods, David R. ; Piper, Rick ; Yarker, Jo ; Begley, Joe ; Smith, Chris ; Hooper, Tim ; Stacey, Mike ; Boos, Christopher ; Mellor, Adrian ; O'Hara, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-3330cd8e5a2da40d8fe1598cc6284523140aea511e2d1790837932ed575454fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute-Phase Proteins</topic><topic>Adult</topic><topic>Altitude</topic><topic>Altitude Sickness - blood</topic><topic>Altitude Sickness - diagnosis</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Clinical Study</topic><topic>Exercise</topic><topic>Female</topic><topic>Humans</topic><topic>Hypoxia - blood</topic><topic>Lipocalin-2</topic><topic>Lipocalins - blood</topic><topic>Male</topic><topic>Proto-Oncogene Proteins - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>King, Rod</creatorcontrib><creatorcontrib>Turner, Steve</creatorcontrib><creatorcontrib>Woods, David R.</creatorcontrib><creatorcontrib>Piper, Rick</creatorcontrib><creatorcontrib>Yarker, Jo</creatorcontrib><creatorcontrib>Begley, Joe</creatorcontrib><creatorcontrib>Smith, Chris</creatorcontrib><creatorcontrib>Hooper, Tim</creatorcontrib><creatorcontrib>Stacey, Mike</creatorcontrib><creatorcontrib>Boos, Christopher</creatorcontrib><creatorcontrib>Mellor, Adrian</creatorcontrib><creatorcontrib>O'Hara, John</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>King, Rod</au><au>Turner, Steve</au><au>Woods, David R.</au><au>Piper, Rick</au><au>Yarker, Jo</au><au>Begley, Joe</au><au>Smith, Chris</au><au>Hooper, Tim</au><au>Stacey, Mike</au><au>Boos, Christopher</au><au>Mellor, Adrian</au><au>O'Hara, John</au><au>Lapaire, Olav</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neutrophil Gelatinase-Associated Lipocalin: Its Response to Hypoxia and Association with Acute Mountain Sickness</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>2013</volume><issue>2013</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Acute Mountain Sickness (AMS) is a common clinical challenge at high altitude (HA). A point-of-care biochemical marker for AMS could have widespread utility. Neutrophil gelatinase-associated lipocalin (NGAL) rises in response to renal injury, inflammation and oxidative stress. We investigated whether NGAL rises with HA and if this rise was related to AMS, hypoxia or exercise. NGAL was assayed in a cohort (n=22) undertaking 6 hours exercise at near sea-level (SL); a cohort (n=14) during 3 hours of normobaric hypoxia (FiO2 11.6%) and on two trekking expeditions (n=52) to over 5000 m. NGAL did not change with exercise at SL or following normobaric hypoxia. During the trekking expeditions NGAL levels (ng/ml, mean ± sd, range) rose significantly (P<0.001) from 68 ± 14 (60–102) at 1300 m to 183 ± 107 (65–519); 143 ± 66 (60–315) and 150 ± 71 (60–357) at 3400 m, 4270 m and 5150 m respectively. At 5150 m there was a significant difference in NGAL between those with severe AMS (n=7), mild AMS (n=16) or no AMS (n=23): 201 ± 34 versus 171 ± 19 versus 124 ± 12 respectively (P=0.009 for severe versus no AMS; P=0.026 for mild versus no AMS). In summary, NGAL rises in response to prolonged hypobaric hypoxia and demonstrates a relationship to the presence and severity of AMS.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>24227892</pmid><doi>10.1155/2013/601214</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-4971-3939</orcidid><orcidid>https://orcid.org/0000-0002-9061-5177</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
| subjects | Acute-Phase Proteins Adult Altitude Altitude Sickness - blood Altitude Sickness - diagnosis Biomarkers - blood Case-Control Studies Clinical Study Exercise Female Humans Hypoxia - blood Lipocalin-2 Lipocalins - blood Male Proto-Oncogene Proteins - blood |
| title | Neutrophil Gelatinase-Associated Lipocalin: Its Response to Hypoxia and Association with Acute Mountain Sickness |
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