MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines

The vagus nerve can control inflammatory response through a ＇cholinergic anti-inflammatory pathway＇, which is mediated by the α7-nicotinic acetylcholine receptor （α7nAChR） on macrophages. However, the intracellular mechanisms that link a7nAChR activation and pro-inflammatory cytokine production rema...

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Veröffentlicht in:	Cell research 2013-11, Vol.23 (11), p.1270-1283
Hauptverfasser:	Sun, Yang, Li, Qi, Gui, Huan, Xu, Dong-Ping, Yang, Yi-Li, Su, Ding-Feng, Liu, Xia
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/127 631/250/2504/342 631/250/256 631/337/384/331 Acetylcholine receptors ADAM Proteins - metabolism ADAM17 Protein alpha7 Nicotinic Acetylcholine Receptor - metabolism Animals Biomedical and Life Sciences Cell Biology Cells, Cultured Cholinergic Neurons - metabolism Cytokines - biosynthesis Cytokines - genetics Cytokines - secretion HEK293 Cells Humans Interleukin-6 - biosynthesis Interleukin-6 - genetics Life Sciences Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - pharmacology Macrophages - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL MicroRNAs - metabolism Original original-article Sepsis - chemically induced Sepsis - genetics Sepsis - metabolism Sepsis - pathology siRNA STAT3 STAT3 Transcription Factor - metabolism TNF-α Transcription, Genetic Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics 乙酰胆碱受体介导抗炎作用细胞因子胆碱能
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