Synthesis and antiproliferative activities of quebecol and its analogs

Total synthesis of quebecol and its derivatives and evaluation of their antiproliferative activities are reported. Simple and efficient synthesis of quebecol and a number of its analogs was accomplished in five steps. The synthesized compounds were evaluated for antiproliferative activities against...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2013-10, Vol.23 (19), p.5329-5331
Hauptverfasser:	Pericherla, Kasiviswanadharaju, Shirazi, Amir Nasrolahi, Kameshwara Rao, V., Tiwari, Rakesh K., DaSilva, Nicholas, McCaffrey, Kellen T., Beni, Yousef A., González-Sarrías, Antonio, Seeram, Navindra P., Parang, Keykavous, Kumar, Anil
Format:	Artikel
Sprache:	eng
Schlagworte:	adenocarcinoma Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antiproliferative Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects cervix chemistry colorectal neoplasms Female Guaiacol - analogs & derivatives Guaiacol - chemical synthesis Guaiacol - chemistry Guaiacol - pharmacology HeLa Cells Humans Inhibitory Concentration 50 Neoplasms - drug therapy Phenolic Propanols - chemical synthesis Propanols - chemistry Propanols - pharmacology Quebecol Structure-Activity Relationship Synthesis
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