Euglycemic Hyperinsulinemia Increases Blood Pressure in Pregnant Rats Independent of Placental Antiangiogenic and Inflammatory Factors

BACKGROUND Although pregnancies associated with hyperinsulinemia and altered placental angiogenic and inflammatory factors are at increased risk for developing preeclampsia, the effects of euglycemic hyperinsulinemia on placental factors and blood pressure regulation during pregnancy are unclear. We...

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Veröffentlicht in:	American journal of hypertension 2013-12, Vol.26 (12), p.1445-1451
Hauptverfasser:	Palei, Ana C., Spradley, Frank T., Granger, Joey P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - blood Blood Pressure - drug effects Cholesterol - blood Disease Models, Animal Fatty acids Female Fetuses Glucose - metabolism Heart Rate - drug effects Hyperinsulinism - blood Hypertension - blood Insulin Insulin - blood Leptin - blood Original Placenta - physiopathology Pre-Eclampsia - blood Pre-Eclampsia - physiopathology Preeclampsia Pregnancy Random Allocation Rats Rats, Sprague-Dawley Rodents Triglycerides - blood Tumor Necrosis Factor-alpha - blood Vascular Endothelial Growth Factor Receptor-1 - blood
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