Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile
Leptin, an adipose‐secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lepob/ob and wild‐type mice. Leptin deficiency results in an...
Gespeichert in:
| Veröffentlicht in: | American journal of transplantation 2013-01, Vol.13 (1), p.36-44 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 44 |
|---|---|
| container_issue | 1 |
| container_start_page | 36 |
| container_title | American journal of transplantation |
| container_volume | 13 |
| creator | Moraes‐Vieira, P. M. M. Bassi, E. J. Larocca, R. A. Castoldi, A. Burghos, M. Lepique, A. P. Quintana, F. J. Araujo, R. C. Basso, A. S. Strom, T. B. Câmara, N. O. S. |
| description | Leptin, an adipose‐secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lepob/ob and wild‐type mice. Leptin deficiency results in an increased frequency of Treg and Th2 cells and a prolonged graft survival. These effects of leptin deficiency indicate the importance of leptin and obesity in modulating the allograft immune responses. Our data suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.
The authors suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection. |
| doi_str_mv | 10.1111/j.1600-6143.2012.04283.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3816358</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3104429021</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5093-eba7d58fe21ee1fc319a6e3044dfe0290f73f488531898cd30010c6482665213</originalsourceid><addsrcrecordid>eNqNUUtvEzEYXCEqWgr_wRJC4pLF7_UeQIoqSouCWkE4W47XTh157WDvhubf422iSOWELx7pm5nvMVUFEKxReR83NeIQzjiipMYQ4RpSLEj9-KK6OBVenjBh59XrnDcQogYL_Ko6xwQi3rD2ovq1MNvBBfA9dqNXg8lg7n1cJ2UH8HNMO7dTHqz24FrtYnJhDRRYPmCgQlfQD7OeRDHtwW3fj8GA-xSt8-ZNdWaVz-bt8b-sltdfllc3s8Xd19ur-WKmGWzJzKxU0zFhDUbGIKsJahU3BFLaWQNxC21DLBWCESRaoTtSNoCaU4E5ZxiRy-rzwXY7rnrTaROGpLzcJtertJdROfm8EtyDXMedJAJxwkQx-HA0SPH3aPIge5e18V4FE8csEW5wAyGhrFDf_UPdxDGFsp1ElBLackbawhIHlk4x52TsaRgE5RSd3MgpFTklJKfo5FN08rFI3x8bqKyVt0kF7fJJj3kLGcbTzJ8OvD_l0Pv_9pfzb8sJkb_amalV</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1443496539</pqid></control><display><type>article</type><title>Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile</title><source>Wiley-Blackwell Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Moraes‐Vieira, P. M. M. ; Bassi, E. J. ; Larocca, R. A. ; Castoldi, A. ; Burghos, M. ; Lepique, A. P. ; Quintana, F. J. ; Araujo, R. C. ; Basso, A. S. ; Strom, T. B. ; Câmara, N. O. S.</creator><creatorcontrib>Moraes‐Vieira, P. M. M. ; Bassi, E. J. ; Larocca, R. A. ; Castoldi, A. ; Burghos, M. ; Lepique, A. P. ; Quintana, F. J. ; Araujo, R. C. ; Basso, A. S. ; Strom, T. B. ; Câmara, N. O. S.</creatorcontrib><description>Leptin, an adipose‐secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lepob/ob and wild‐type mice. Leptin deficiency results in an increased frequency of Treg and Th2 cells and a prolonged graft survival. These effects of leptin deficiency indicate the importance of leptin and obesity in modulating the allograft immune responses. Our data suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.
The authors suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/j.1600-6143.2012.04283.x</identifier><identifier>PMID: 23016759</identifier><language>eng</language><publisher>Hoboken, NJ: Wiley</publisher><subject>Alloimmunity ; Animal models ; Biological and medical sciences ; Cell survival ; Data processing ; Graft rejection ; Helper cells ; Hormones ; Immune response ; Leptin ; Lymphocytes T ; Medical sciences ; Metabolism ; Obesity ; regulatory T cell ; Rodents ; Skin ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Survival ; tolerance ; Transplants & implants</subject><ispartof>American journal of transplantation, 2013-01, Vol.13 (1), p.36-44</ispartof><rights>Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>2014 INIST-CNRS</rights><rights>2012 American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>Copyright 2012 The American Society of Transplantation 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5093-eba7d58fe21ee1fc319a6e3044dfe0290f73f488531898cd30010c6482665213</citedby><cites>FETCH-LOGICAL-c5093-eba7d58fe21ee1fc319a6e3044dfe0290f73f488531898cd30010c6482665213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-6143.2012.04283.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-6143.2012.04283.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26905228$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Moraes‐Vieira, P. M. M.</creatorcontrib><creatorcontrib>Bassi, E. J.</creatorcontrib><creatorcontrib>Larocca, R. A.</creatorcontrib><creatorcontrib>Castoldi, A.</creatorcontrib><creatorcontrib>Burghos, M.</creatorcontrib><creatorcontrib>Lepique, A. P.</creatorcontrib><creatorcontrib>Quintana, F. J.</creatorcontrib><creatorcontrib>Araujo, R. C.</creatorcontrib><creatorcontrib>Basso, A. S.</creatorcontrib><creatorcontrib>Strom, T. B.</creatorcontrib><creatorcontrib>Câmara, N. O. S.</creatorcontrib><title>Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile</title><title>American journal of transplantation</title><description>Leptin, an adipose‐secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lepob/ob and wild‐type mice. Leptin deficiency results in an increased frequency of Treg and Th2 cells and a prolonged graft survival. These effects of leptin deficiency indicate the importance of leptin and obesity in modulating the allograft immune responses. Our data suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.
The authors suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.</description><subject>Alloimmunity</subject><subject>Animal models</subject><subject>Biological and medical sciences</subject><subject>Cell survival</subject><subject>Data processing</subject><subject>Graft rejection</subject><subject>Helper cells</subject><subject>Hormones</subject><subject>Immune response</subject><subject>Leptin</subject><subject>Lymphocytes T</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Obesity</subject><subject>regulatory T cell</subject><subject>Rodents</subject><subject>Skin</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Survival</subject><subject>tolerance</subject><subject>Transplants & implants</subject><issn>1600-6135</issn><issn>1600-6143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNUUtvEzEYXCEqWgr_wRJC4pLF7_UeQIoqSouCWkE4W47XTh157WDvhubf422iSOWELx7pm5nvMVUFEKxReR83NeIQzjiipMYQ4RpSLEj9-KK6OBVenjBh59XrnDcQogYL_Ko6xwQi3rD2ovq1MNvBBfA9dqNXg8lg7n1cJ2UH8HNMO7dTHqz24FrtYnJhDRRYPmCgQlfQD7OeRDHtwW3fj8GA-xSt8-ZNdWaVz-bt8b-sltdfllc3s8Xd19ur-WKmGWzJzKxU0zFhDUbGIKsJahU3BFLaWQNxC21DLBWCESRaoTtSNoCaU4E5ZxiRy-rzwXY7rnrTaROGpLzcJtertJdROfm8EtyDXMedJAJxwkQx-HA0SPH3aPIge5e18V4FE8csEW5wAyGhrFDf_UPdxDGFsp1ElBLackbawhIHlk4x52TsaRgE5RSd3MgpFTklJKfo5FN08rFI3x8bqKyVt0kF7fJJj3kLGcbTzJ8OvD_l0Pv_9pfzb8sJkb_amalV</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Moraes‐Vieira, P. M. M.</creator><creator>Bassi, E. J.</creator><creator>Larocca, R. A.</creator><creator>Castoldi, A.</creator><creator>Burghos, M.</creator><creator>Lepique, A. P.</creator><creator>Quintana, F. J.</creator><creator>Araujo, R. C.</creator><creator>Basso, A. S.</creator><creator>Strom, T. B.</creator><creator>Câmara, N. O. S.</creator><general>Wiley</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>5PM</scope></search><sort><creationdate>201301</creationdate><title>Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile</title><author>Moraes‐Vieira, P. M. M. ; Bassi, E. J. ; Larocca, R. A. ; Castoldi, A. ; Burghos, M. ; Lepique, A. P. ; Quintana, F. J. ; Araujo, R. C. ; Basso, A. S. ; Strom, T. B. ; Câmara, N. O. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5093-eba7d58fe21ee1fc319a6e3044dfe0290f73f488531898cd30010c6482665213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alloimmunity</topic><topic>Animal models</topic><topic>Biological and medical sciences</topic><topic>Cell survival</topic><topic>Data processing</topic><topic>Graft rejection</topic><topic>Helper cells</topic><topic>Hormones</topic><topic>Immune response</topic><topic>Leptin</topic><topic>Lymphocytes T</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Obesity</topic><topic>regulatory T cell</topic><topic>Rodents</topic><topic>Skin</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Survival</topic><topic>tolerance</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moraes‐Vieira, P. M. M.</creatorcontrib><creatorcontrib>Bassi, E. J.</creatorcontrib><creatorcontrib>Larocca, R. A.</creatorcontrib><creatorcontrib>Castoldi, A.</creatorcontrib><creatorcontrib>Burghos, M.</creatorcontrib><creatorcontrib>Lepique, A. P.</creatorcontrib><creatorcontrib>Quintana, F. J.</creatorcontrib><creatorcontrib>Araujo, R. C.</creatorcontrib><creatorcontrib>Basso, A. S.</creatorcontrib><creatorcontrib>Strom, T. B.</creatorcontrib><creatorcontrib>Câmara, N. O. S.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moraes‐Vieira, P. M. M.</au><au>Bassi, E. J.</au><au>Larocca, R. A.</au><au>Castoldi, A.</au><au>Burghos, M.</au><au>Lepique, A. P.</au><au>Quintana, F. J.</au><au>Araujo, R. C.</au><au>Basso, A. S.</au><au>Strom, T. B.</au><au>Câmara, N. O. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile</atitle><jtitle>American journal of transplantation</jtitle><date>2013-01</date><risdate>2013</risdate><volume>13</volume><issue>1</issue><spage>36</spage><epage>44</epage><pages>36-44</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><abstract>Leptin, an adipose‐secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lepob/ob and wild‐type mice. Leptin deficiency results in an increased frequency of Treg and Th2 cells and a prolonged graft survival. These effects of leptin deficiency indicate the importance of leptin and obesity in modulating the allograft immune responses. Our data suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.
The authors suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.</abstract><cop>Hoboken, NJ</cop><pub>Wiley</pub><pmid>23016759</pmid><doi>10.1111/j.1600-6143.2012.04283.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1600-6135 |
| ispartof | American journal of transplantation, 2013-01, Vol.13 (1), p.36-44 |
| issn | 1600-6135 1600-6143 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3816358 |
| source | Wiley-Blackwell Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Alloimmunity Animal models Biological and medical sciences Cell survival Data processing Graft rejection Helper cells Hormones Immune response Leptin Lymphocytes T Medical sciences Metabolism Obesity regulatory T cell Rodents Skin Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Survival tolerance Transplants & implants |
| title | Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T05%3A43%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Leptin%20Modulates%20Allograft%20Survival%20by%20Favoring%20a%20Th2%20and%20a%20Regulatory%20Immune%20Profile&rft.jtitle=American%20journal%20of%20transplantation&rft.au=Moraes%E2%80%90Vieira,%20P.%20M.%20M.&rft.date=2013-01&rft.volume=13&rft.issue=1&rft.spage=36&rft.epage=44&rft.pages=36-44&rft.issn=1600-6135&rft.eissn=1600-6143&rft_id=info:doi/10.1111/j.1600-6143.2012.04283.x&rft_dat=%3Cproquest_pubme%3E3104429021%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1443496539&rft_id=info:pmid/23016759&rfr_iscdi=true |