J‐LEAPS peptide and LEAPS dendritic cell vaccines
Summary The J‐LEAPS vaccines contain a peptide from β‐2‐microglobulin covalently attached to disease‐related peptides of 8–30 amino acids which contain a T cell epitope. The J‐LEAPS vaccines can initiate a protective Th1 immune response or modulate an ongoing Th17 autoimmune response to the peptide....
Gespeichert in:
| Veröffentlicht in: | Microbial biotechnology 2012-03, Vol.5 (2), p.203-213 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 213 |
|---|---|
| container_issue | 2 |
| container_start_page | 203 |
| container_title | Microbial biotechnology |
| container_volume | 5 |
| creator | Rosenthal, Ken S. Taylor, Patricia Zimmerman, Daniel H. |
| description | Summary
The J‐LEAPS vaccines contain a peptide from β‐2‐microglobulin covalently attached to disease‐related peptides of 8–30 amino acids which contain a T cell epitope. The J‐LEAPS vaccines can initiate a protective Th1 immune response or modulate an ongoing Th17 autoimmune response to the peptide. J‐LEAPS vaccines activate and direct the nature of the subsequent immune response by promoting the maturation of precursor cells into a unique type of dendritic cell that produces interleukin 12, but not IL‐1 or tumour necrosis factor, and presents the antigenic peptide to T cells. Adoptive transfer of JgD‐LEAPS dendritic cells, matured with an anti‐HSV‐1 vaccine, promoted antigen‐specific Th1 protection against lethal challenge with the virus. J‐LEAPS peptide immunogens and J‐LEAPS dendritic cell vaccines have potential applications for antimicrobial prevention and therapy, treatment of autoimmune diseases, and for cancer immunotherapy. |
| doi_str_mv | 10.1111/j.1751-7915.2011.00278.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3815780</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2299173812</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5008-d6ed2ba4ba11411246200c546ef641744bf38701ea2a78a8ee63c36491604fab3</originalsourceid><addsrcrecordid>eNqNkd1u1DAQhS1ERUvhFVAkLrjaMOM4_pEQUrtqC9WiIlGuLceZtF5lkyXe7c8dj9Bn5EnqdMuqcFXfeOT55shnDmMZQo7pfJznqEqcKINlzgExB-BK5zcv2N628fJJvctexzgHkAAlf8V2OWpTGsP3WHH65_fd7Ojg-49sSctVqClzXZ1tXmrq6iGsgs88tW125bwPHcU3bKdxbaS3j_c--3l8dD79MpmdnXydHswmvgTQk1pSzSsnKocoELmQHMCXQlIjBSohqqbQCpAcd0o7TSQLX0hhUIJoXFXss88b3eW6WlDtqVsNrrXLISzccGt7F-y_nS5c2ov-yhYaS6UhCXx4FBj6X2uKK7sIcbTiOurX0RrOlQRpZCLf_0fO-_XQJXeWc2NQJUmeKL2h_NDHOFCz_QuCHYOxczvu3I47t2Mw9iEYe5NG3z31sh38m0QCPm2A69DS7bOF7bfD81QU99rbmnU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2299173812</pqid></control><display><type>article</type><title>J‐LEAPS peptide and LEAPS dendritic cell vaccines</title><source>Wiley Online Library Open Access</source><creator>Rosenthal, Ken S. ; Taylor, Patricia ; Zimmerman, Daniel H.</creator><creatorcontrib>Rosenthal, Ken S. ; Taylor, Patricia ; Zimmerman, Daniel H.</creatorcontrib><description>Summary
The J‐LEAPS vaccines contain a peptide from β‐2‐microglobulin covalently attached to disease‐related peptides of 8–30 amino acids which contain a T cell epitope. The J‐LEAPS vaccines can initiate a protective Th1 immune response or modulate an ongoing Th17 autoimmune response to the peptide. J‐LEAPS vaccines activate and direct the nature of the subsequent immune response by promoting the maturation of precursor cells into a unique type of dendritic cell that produces interleukin 12, but not IL‐1 or tumour necrosis factor, and presents the antigenic peptide to T cells. Adoptive transfer of JgD‐LEAPS dendritic cells, matured with an anti‐HSV‐1 vaccine, promoted antigen‐specific Th1 protection against lethal challenge with the virus. J‐LEAPS peptide immunogens and J‐LEAPS dendritic cell vaccines have potential applications for antimicrobial prevention and therapy, treatment of autoimmune diseases, and for cancer immunotherapy.</description><identifier>ISSN: 1751-7915</identifier><identifier>EISSN: 1751-7915</identifier><identifier>DOI: 10.1111/j.1751-7915.2011.00278.x</identifier><identifier>PMID: 21895992</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adoptive transfer ; Amino acids ; Antigens ; Antigens - genetics ; Antigens - immunology ; Autoimmune diseases ; Autoimmune Diseases - therapy ; beta 2-Microglobulin - genetics ; beta 2-Microglobulin - immunology ; Cancer immunotherapy ; Cancer therapies ; Communicable Disease Control - methods ; Cytokines ; Dendritic cells ; Dendritic Cells - immunology ; Dendritic structure ; Epitopes ; Glycoproteins ; Helper cells ; Humans ; Immune response ; Immune system ; Immunotherapy ; Immunotherapy - methods ; Infections ; Interleukin 12 ; Ligands ; Lymphocytes ; Lymphocytes T ; Medical treatment ; Minireviews ; Neoplasms - therapy ; Peptides ; Proteins ; Recombinant Fusion Proteins - genetics ; Recombinant Fusion Proteins - immunology ; T cell receptors ; Tumor necrosis factor ; Tumors ; Vaccines ; Viruses</subject><ispartof>Microbial biotechnology, 2012-03, Vol.5 (2), p.203-213</ispartof><rights>2011 The Authors. Journal compilation © 2011 Society for Applied Microbiology and Blackwell Publishing Ltd</rights><rights>2011 The Authors. Journal compilation © 2011 Society for Applied Microbiology and Blackwell Publishing Ltd.</rights><rights>Copyright John Wiley & Sons, Inc. Mar 2012</rights><rights>Copyright © 2011 The Authors. Journal compilation © 2011 Society for Applied Microbiology and Blackwell Publishing Ltd 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5008-d6ed2ba4ba11411246200c546ef641744bf38701ea2a78a8ee63c36491604fab3</citedby><cites>FETCH-LOGICAL-c5008-d6ed2ba4ba11411246200c546ef641744bf38701ea2a78a8ee63c36491604fab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815780/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815780/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1751-7915.2011.00278.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21895992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosenthal, Ken S.</creatorcontrib><creatorcontrib>Taylor, Patricia</creatorcontrib><creatorcontrib>Zimmerman, Daniel H.</creatorcontrib><title>J‐LEAPS peptide and LEAPS dendritic cell vaccines</title><title>Microbial biotechnology</title><addtitle>Microb Biotechnol</addtitle><description>Summary
The J‐LEAPS vaccines contain a peptide from β‐2‐microglobulin covalently attached to disease‐related peptides of 8–30 amino acids which contain a T cell epitope. The J‐LEAPS vaccines can initiate a protective Th1 immune response or modulate an ongoing Th17 autoimmune response to the peptide. J‐LEAPS vaccines activate and direct the nature of the subsequent immune response by promoting the maturation of precursor cells into a unique type of dendritic cell that produces interleukin 12, but not IL‐1 or tumour necrosis factor, and presents the antigenic peptide to T cells. Adoptive transfer of JgD‐LEAPS dendritic cells, matured with an anti‐HSV‐1 vaccine, promoted antigen‐specific Th1 protection against lethal challenge with the virus. J‐LEAPS peptide immunogens and J‐LEAPS dendritic cell vaccines have potential applications for antimicrobial prevention and therapy, treatment of autoimmune diseases, and for cancer immunotherapy.</description><subject>Adoptive transfer</subject><subject>Amino acids</subject><subject>Antigens</subject><subject>Antigens - genetics</subject><subject>Antigens - immunology</subject><subject>Autoimmune diseases</subject><subject>Autoimmune Diseases - therapy</subject><subject>beta 2-Microglobulin - genetics</subject><subject>beta 2-Microglobulin - immunology</subject><subject>Cancer immunotherapy</subject><subject>Cancer therapies</subject><subject>Communicable Disease Control - methods</subject><subject>Cytokines</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - immunology</subject><subject>Dendritic structure</subject><subject>Epitopes</subject><subject>Glycoproteins</subject><subject>Helper cells</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunotherapy</subject><subject>Immunotherapy - methods</subject><subject>Infections</subject><subject>Interleukin 12</subject><subject>Ligands</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Medical treatment</subject><subject>Minireviews</subject><subject>Neoplasms - therapy</subject><subject>Peptides</subject><subject>Proteins</subject><subject>Recombinant Fusion Proteins - genetics</subject><subject>Recombinant Fusion Proteins - immunology</subject><subject>T cell receptors</subject><subject>Tumor necrosis factor</subject><subject>Tumors</subject><subject>Vaccines</subject><subject>Viruses</subject><issn>1751-7915</issn><issn>1751-7915</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkd1u1DAQhS1ERUvhFVAkLrjaMOM4_pEQUrtqC9WiIlGuLceZtF5lkyXe7c8dj9Bn5EnqdMuqcFXfeOT55shnDmMZQo7pfJznqEqcKINlzgExB-BK5zcv2N628fJJvctexzgHkAAlf8V2OWpTGsP3WHH65_fd7Ojg-49sSctVqClzXZ1tXmrq6iGsgs88tW125bwPHcU3bKdxbaS3j_c--3l8dD79MpmdnXydHswmvgTQk1pSzSsnKocoELmQHMCXQlIjBSohqqbQCpAcd0o7TSQLX0hhUIJoXFXss88b3eW6WlDtqVsNrrXLISzccGt7F-y_nS5c2ov-yhYaS6UhCXx4FBj6X2uKK7sIcbTiOurX0RrOlQRpZCLf_0fO-_XQJXeWc2NQJUmeKL2h_NDHOFCz_QuCHYOxczvu3I47t2Mw9iEYe5NG3z31sh38m0QCPm2A69DS7bOF7bfD81QU99rbmnU</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>Rosenthal, Ken S.</creator><creator>Taylor, Patricia</creator><creator>Zimmerman, Daniel H.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T7</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>M7S</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201203</creationdate><title>J‐LEAPS peptide and LEAPS dendritic cell vaccines</title><author>Rosenthal, Ken S. ; Taylor, Patricia ; Zimmerman, Daniel H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5008-d6ed2ba4ba11411246200c546ef641744bf38701ea2a78a8ee63c36491604fab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adoptive transfer</topic><topic>Amino acids</topic><topic>Antigens</topic><topic>Antigens - genetics</topic><topic>Antigens - immunology</topic><topic>Autoimmune diseases</topic><topic>Autoimmune Diseases - therapy</topic><topic>beta 2-Microglobulin - genetics</topic><topic>beta 2-Microglobulin - immunology</topic><topic>Cancer immunotherapy</topic><topic>Cancer therapies</topic><topic>Communicable Disease Control - methods</topic><topic>Cytokines</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - immunology</topic><topic>Dendritic structure</topic><topic>Epitopes</topic><topic>Glycoproteins</topic><topic>Helper cells</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunotherapy</topic><topic>Immunotherapy - methods</topic><topic>Infections</topic><topic>Interleukin 12</topic><topic>Ligands</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Medical treatment</topic><topic>Minireviews</topic><topic>Neoplasms - therapy</topic><topic>Peptides</topic><topic>Proteins</topic><topic>Recombinant Fusion Proteins - genetics</topic><topic>Recombinant Fusion Proteins - immunology</topic><topic>T cell receptors</topic><topic>Tumor necrosis factor</topic><topic>Tumors</topic><topic>Vaccines</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosenthal, Ken S.</creatorcontrib><creatorcontrib>Taylor, Patricia</creatorcontrib><creatorcontrib>Zimmerman, Daniel H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Microbial biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Rosenthal, Ken S.</au><au>Taylor, Patricia</au><au>Zimmerman, Daniel H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>J‐LEAPS peptide and LEAPS dendritic cell vaccines</atitle><jtitle>Microbial biotechnology</jtitle><addtitle>Microb Biotechnol</addtitle><date>2012-03</date><risdate>2012</risdate><volume>5</volume><issue>2</issue><spage>203</spage><epage>213</epage><pages>203-213</pages><issn>1751-7915</issn><eissn>1751-7915</eissn><abstract>Summary
The J‐LEAPS vaccines contain a peptide from β‐2‐microglobulin covalently attached to disease‐related peptides of 8–30 amino acids which contain a T cell epitope. The J‐LEAPS vaccines can initiate a protective Th1 immune response or modulate an ongoing Th17 autoimmune response to the peptide. J‐LEAPS vaccines activate and direct the nature of the subsequent immune response by promoting the maturation of precursor cells into a unique type of dendritic cell that produces interleukin 12, but not IL‐1 or tumour necrosis factor, and presents the antigenic peptide to T cells. Adoptive transfer of JgD‐LEAPS dendritic cells, matured with an anti‐HSV‐1 vaccine, promoted antigen‐specific Th1 protection against lethal challenge with the virus. J‐LEAPS peptide immunogens and J‐LEAPS dendritic cell vaccines have potential applications for antimicrobial prevention and therapy, treatment of autoimmune diseases, and for cancer immunotherapy.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21895992</pmid><doi>10.1111/j.1751-7915.2011.00278.x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1751-7915 |
| ispartof | Microbial biotechnology, 2012-03, Vol.5 (2), p.203-213 |
| issn | 1751-7915 1751-7915 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3815780 |
| source | Wiley Online Library Open Access |
| subjects | Adoptive transfer Amino acids Antigens Antigens - genetics Antigens - immunology Autoimmune diseases Autoimmune Diseases - therapy beta 2-Microglobulin - genetics beta 2-Microglobulin - immunology Cancer immunotherapy Cancer therapies Communicable Disease Control - methods Cytokines Dendritic cells Dendritic Cells - immunology Dendritic structure Epitopes Glycoproteins Helper cells Humans Immune response Immune system Immunotherapy Immunotherapy - methods Infections Interleukin 12 Ligands Lymphocytes Lymphocytes T Medical treatment Minireviews Neoplasms - therapy Peptides Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology T cell receptors Tumor necrosis factor Tumors Vaccines Viruses |
| title | J‐LEAPS peptide and LEAPS dendritic cell vaccines |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T15%3A43%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_24P&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=J%E2%80%90LEAPS%20peptide%20and%20LEAPS%20dendritic%20cell%20vaccines&rft.jtitle=Microbial%20biotechnology&rft.au=Rosenthal,%20Ken%20S.&rft.date=2012-03&rft.volume=5&rft.issue=2&rft.spage=203&rft.epage=213&rft.pages=203-213&rft.issn=1751-7915&rft.eissn=1751-7915&rft_id=info:doi/10.1111/j.1751-7915.2011.00278.x&rft_dat=%3Cproquest_24P%3E2299173812%3C/proquest_24P%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2299173812&rft_id=info:pmid/21895992&rfr_iscdi=true |