Using proteomics to uncover extracellular matrix interactions during cardiac remodeling
The left ventricle (LV) responds to a myocardial infarction with an orchestrated sequence of events that result in fundamental changes to both the structure and function of the myocardium. This collection of responses is termed as LV remodeling. Myocardial ischemia resulting in necrosis is the initi...
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| Veröffentlicht in: | Proteomics. Clinical applications 2013-08, Vol.7 (7-8), p.516-527 |
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| creator | Patterson, Nicolle L. Iyer, Rugmani Padmanabhan de Castro Brás, Lisandra E. Li, Yaojun Andrews, Thomas G. Aune, Gregory J. Lange, Richard A. Lindsey, Merry L. |
| description | The left ventricle (LV) responds to a myocardial infarction with an orchestrated sequence of events that result in fundamental changes to both the structure and function of the myocardium. This collection of responses is termed as LV remodeling. Myocardial ischemia resulting in necrosis is the initiating event that culminates in the formation of an extracellular matrix (ECM) rich infarct scar that replaces necrotic myocytes. While the cardiomyocyte is the major cell type that responds to ischemia, infiltrating leukocytes and cardiac fibroblasts coordinate the subsequent wound healing response. The matrix metalloproteinase family of enzymes regulates the inflammatory and ECM responses that modulate scar formation. Matridomics is the proteomic evaluation focused on ECM, while degradomics is the proteomic evaluation of proteases as well as their inhibitors and substrates. This review will summarize the use of proteomics to better understand matrix metalloproteinase roles in post myocardial infarction LV remodeling. |
| doi_str_mv | 10.1002/prca.201200100 |
| format | Article |
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This collection of responses is termed as LV remodeling. Myocardial ischemia resulting in necrosis is the initiating event that culminates in the formation of an extracellular matrix (ECM) rich infarct scar that replaces necrotic myocytes. While the cardiomyocyte is the major cell type that responds to ischemia, infiltrating leukocytes and cardiac fibroblasts coordinate the subsequent wound healing response. The matrix metalloproteinase family of enzymes regulates the inflammatory and ECM responses that modulate scar formation. Matridomics is the proteomic evaluation focused on ECM, while degradomics is the proteomic evaluation of proteases as well as their inhibitors and substrates. 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This review will summarize the use of proteomics to better understand matrix metalloproteinase roles in post myocardial infarction LV remodeling.</description><subject>Animals</subject><subject>Degradomics</subject><subject>Extracellular Matrix - metabolism</subject><subject>Extracellular Matrix - pathology</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Matridomics</subject><subject>Matrix metalloproteinases</subject><subject>Myocardial infarction</subject><subject>Proteolysis</subject><subject>Proteomics</subject><subject>Proteomics - methods</subject><subject>Ventricular Remodeling</subject><issn>1862-8346</issn><issn>1862-8354</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1PFDEYxhuiAUSvHs0kXrjM2s9p52JCNggmq6KRwK3ptu9gcWa6tDOw_Pd2szhBL3Dp5-95-rx9EXpL8IxgTD-sojUzignFOO930D5RFS0VE_zFtObVHnqV0jXGglOJd9EeZYLRmsp9dHGefH9VrGIYIHTepmIIxdjbcAuxgPUQjYW2HVsTi84M0a8L3w-QTwcf-lS4MW7k1kTnjS0idMFBm49eo5eNaRO8eZgP0Pmn45_z03Lx7eTz_GhR2irHKYmrGqckVUqAMJbUTbPkCiqxNIpUhBvmCJMy12BrDNy52jSEA6ulkzV1S3aAPm59V-OyA2ehz5FbvYq-M_FeB-P1vze9_6Wvwq1migghVDY4fDCI4WaENOjOp03NpocwJk04kyK_xZ6FcpwHijP6_j_0Ooyxzz-RKaKwUnUlMzXbUjaGlCI0U26C9aa9etNePbU3C949rnbC__YzA3wL3PkW7p-w02c_5keEVyLLyq3MpwHWk8zE3zrHlEJffD3R6rtYfKnxmb5kfwCLpMEq</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Patterson, Nicolle L.</creator><creator>Iyer, Rugmani Padmanabhan</creator><creator>de Castro Brás, Lisandra E.</creator><creator>Li, Yaojun</creator><creator>Andrews, Thomas G.</creator><creator>Aune, Gregory J.</creator><creator>Lange, Richard A.</creator><creator>Lindsey, Merry L.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7QO</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201308</creationdate><title>Using proteomics to uncover extracellular matrix interactions during cardiac remodeling</title><author>Patterson, Nicolle L. ; Iyer, Rugmani Padmanabhan ; de Castro Brás, Lisandra E. ; Li, Yaojun ; Andrews, Thomas G. ; Aune, Gregory J. ; Lange, Richard A. ; Lindsey, Merry L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6005-1d6fd872885e5ac19ffb48e65ba81614a3d1377834c90e4dd9af14e397d792db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Degradomics</topic><topic>Extracellular Matrix - metabolism</topic><topic>Extracellular Matrix - pathology</topic><topic>Extracellular Matrix Proteins - metabolism</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Matridomics</topic><topic>Matrix metalloproteinases</topic><topic>Myocardial infarction</topic><topic>Proteolysis</topic><topic>Proteomics</topic><topic>Proteomics - methods</topic><topic>Ventricular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patterson, Nicolle L.</creatorcontrib><creatorcontrib>Iyer, Rugmani Padmanabhan</creatorcontrib><creatorcontrib>de Castro Brás, Lisandra E.</creatorcontrib><creatorcontrib>Li, Yaojun</creatorcontrib><creatorcontrib>Andrews, Thomas G.</creatorcontrib><creatorcontrib>Aune, Gregory J.</creatorcontrib><creatorcontrib>Lange, Richard A.</creatorcontrib><creatorcontrib>Lindsey, Merry L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proteomics. 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| subjects | Animals Degradomics Extracellular Matrix - metabolism Extracellular Matrix - pathology Extracellular Matrix Proteins - metabolism Heart attacks Humans Ischemia Matridomics Matrix metalloproteinases Myocardial infarction Proteolysis Proteomics Proteomics - methods Ventricular Remodeling |
| title | Using proteomics to uncover extracellular matrix interactions during cardiac remodeling |
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