Spartin Regulates Synaptic Growth and Neuronal Survival by Inhibiting BMP-Mediated Microtubule Stabilization

Troyer syndrome is a hereditary spastic paraplegia caused by human spartin (SPG20) gene mutations. We have generated a Drosophila disease model showing that Spartin functions presynaptically with endocytic adaptor Eps15 to regulate synaptic growth and function. Spartin inhibits bone morphogenetic pr...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2013-02, Vol.77 (4), p.680-695
Hauptverfasser:	Nahm, Minyeop, Lee, Min-Jung, Parkinson, William, Lee, Mihye, Kim, Haeran, Kim, Yoon-Jung, Kim, Sungdae, Cho, Yi Sul, Min, Byung-Moo, Bae, Yong Chul, Broadie, Kendal, Lee, Seungbok
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence - genetics Bone Morphogenetic Protein Receptors - genetics Bone Morphogenetic Protein Receptors - metabolism Bone Morphogenetic Proteins - genetics Cell division Cell Survival Drosophila Drosophila - genetics Genomes Humans Insects Microtubule-Associated Proteins - metabolism Microtubules - genetics Microtubules - metabolism Mutation Neurodegeneration Neurons - cytology Neurons - metabolism Protein Binding - physiology Proteins Signal Transduction - genetics Spastic Paraplegia, Hereditary - genetics Spastic Paraplegia, Hereditary - metabolism Synapses - metabolism
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