Optical imaging to map blood-brain barrier leakage

Vascular leakage in the brain is a major complication associated with brain injuries and certain pathological conditions due to disruption of the blood-brain barrier (BBB). We have developed an optical imaging method, based on excitation and emission spectra of Evans Blue dye, that is >1000-fold...

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Veröffentlicht in:	Scientific reports 2013-11, Vol.3 (1), p.3117-3117, Article 3117
Hauptverfasser:	Jaffer, Hayder, Adjei, Isaac M., Labhasetwar, Vinod
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/527/1819 631/378/1341 639/925/352/2734 692/699/375/534 Animals Blood-brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Brain - drug effects Brain - metabolism Brain - pathology Brain injury Brain mapping Coloring Agents Disease Models, Animal Humanities and Social Sciences Leakage Male multidisciplinary Neuroimaging Optical Imaging - methods Permeability Rats Science Spectrophotometry Stroke Stroke - metabolism Stroke - pathology t-Plasminogen activator Thromboembolism Tissue Plasminogen Activator - pharmacology
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