Immunogenicity of Membrane-bound HIV-1 gp41 Membrane-proximal External Region (MPER) Segments Is Dominated by Residue Accessibility and Modulated by Stereochemistry

Structural characterization of epitope-paratope pairs has contributed to the understanding of antigenicity. By contrast, few structural studies relate to immunogenicity, the process of antigen-induced immune responses in vivo. Using a lipid-arrayed membrane-proximal external region (MPER) of HIV-1 g...

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Veröffentlicht in:	The Journal of biological chemistry 2013-11, Vol.288 (44), p.31888-31901
Hauptverfasser:	Kim, Mikyung, Song, Likai, Moon, James, Sun, Zhen-Yu J., Bershteyn, Anna, Hanson, Melissa, Cain, Derek, Goka, Selasie, Kelsoe, Garnett, Wagner, Gerhard, Irvine, Darrell, Reinherz, Ellis L.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Vaccines - chemistry AIDS Vaccines - genetics AIDS Vaccines - immunology Animals Antibodies Antigens, Viral - chemistry Antigens, Viral - genetics Antigens, Viral - immunology B-Lymphocytes - immunology Epitopes, B-Lymphocyte - chemistry Epitopes, B-Lymphocyte - genetics Epitopes, B-Lymphocyte - immunology HIV Envelope Protein gp41 - chemistry HIV Envelope Protein gp41 - genetics HIV Envelope Protein gp41 - immunology HIV-1 HIV-1 - chemistry HIV-1 - genetics HIV-1 - immunology Humans Immunodominance Immunogenicity Immunology Infectious Diseases Mice Mice, Inbred BALB C Mutagenesis, Site-Directed Peptides - chemistry Peptides - genetics Peptides - immunology Protein Structure Vaccine Development
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