Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice

Mice deleted for the plasminogen activator inhibitor-1 (PAI-1) gene are relatively protected from developing pulmonary fibrosis induced by bleomycin. We hypothesized that PAI-1 deficiency reduces fibrosis by promoting plasminogen activation and accelerating the clearance of fibrin matrices that accu...

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Veröffentlicht in:	The Journal of clinical investigation 2000-12, Vol.106 (11), p.1341-1350
Hauptverfasser:	Hattori, N, Degen, J L, Sisson, T H, Liu, H, Moore, B B, Pandrangi, R G, Simon, R H, Drew, A F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifibrinolytic Agents - pharmacology Bleomycin - pharmacology Bronchoalveolar Lavage Fluid - cytology Capillary Permeability - drug effects Collagen - drug effects Collagen - metabolism Female Fibrin - drug effects Fibrin - metabolism Fibrin - pharmacokinetics Fibrinogen - genetics Fibrinogen - metabolism Fibrinolysin - drug effects Fibrinolysin - metabolism Genotype Kinetics Lung - drug effects Lung - metabolism Lung - pathology Male Metabolic Clearance Rate Mice Mice, Inbred C57BL Mice, Mutant Strains Plasminogen Activator Inhibitor 1 - deficiency Plasminogen Activator Inhibitor 1 - genetics Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - genetics Pulmonary Fibrosis - metabolism Survival Analysis Tranexamic Acid - pharmacology
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