Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats

Thrombospondins (TSPs) are extracellular regulators of cell–matrix interactions and cell phenotype. The most highly conserved region of all TSPs are the calcium‐binding type 3 (T3) repeats and the C‐terminal globular domain (CTD). The crystal structure of a cell‐binding TSP‐1 fragment, spanning thre...

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