Linezolid for Treatment of Chronic Extensively Drug-Resistant Tuberculosis

There are limited therapeutic options for extensively drug-resistant tuberculosis. In this study from South Korea, linezolid was shown to have some activity in treating resistant tuberculosis; however, its use was associated with clinically significant toxicity. Linezolid (Zyvox, Pfizer) was approve...

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Veröffentlicht in:	The New England journal of medicine 2012-10, Vol.367 (16), p.1508-1518
Hauptverfasser:	Lee, Myungsun, Lee, Jongseok, Carroll, Matthew W, Choi, Hongjo, Min, Seonyeong, Song, Taeksun, Via, Laura E, Goldfeder, Lisa C, Kang, Eunhwa, Jin, Boyoung, Park, Hyeeun, Kwak, Hyunkyung, Kim, Hyunchul, Jeon, Han-Seung, Jeong, Ina, Joh, Joon Sung, Chen, Ray Y, Olivier, Kenneth N, Shaw, Pamela A, Follmann, Dean, Song, Sun Dae, Lee, Jong-Koo, Lee, Dukhyoung, Kim, Cheon Tae, Dartois, Veronique, Park, Seung-Kyu, Cho, Sang-Nae, Barry, Clifton E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - adverse effects Acetamides - pharmacokinetics Acetamides - therapeutic use Adult Allergies Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents - adverse effects Antitubercular Agents - pharmacokinetics Antitubercular Agents - therapeutic use Bacterial diseases Biological and medical sciences Drug dosages Drug resistance Drug Resistance, Bacterial Drug Therapy, Combination Extensively Drug-Resistant Tuberculosis - drug therapy Female General aspects Human bacterial diseases Humans Infectious diseases Kaplan-Meier Estimate Linezolid Male Medical sciences Middle Aged Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - isolation & purification Oxazolidinones - adverse effects Oxazolidinones - pharmacokinetics Oxazolidinones - therapeutic use Patients Pharmacology. Drug treatments Protein synthesis Sputum Sputum - microbiology Toxicity Tuberculosis Tuberculosis and atypical mycobacterial infections Young Adult
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