A role for anti-BP180 autoantibodies in chronic rhinosinusitis
Objectives/Hypothesis Chronic Rhinosinusitis (CRS) is accompanied by evidence of a vigorous adaptive immune response, and emerging studies demonstrate that some nasal polyps manifest a polyclonal autoantibody response. We previously found that antibodies against BP180, a component of the hemidesmoso...
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| Veröffentlicht in: | The Laryngoscope 2013-09, Vol.123 (9), p.2104-2111 |
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| creator | Jeffe, Jill S. Seshadri, Sudarshan Hamill, Kevin J. Huang, Julia He Carter, Roderick Suh, Lydia Hulse, Kathryn E. Norton, James Conley, David B. Chandra, Rakesh K. Kern, Robert C. Jones, Jonathan C. R. Schleimer, Robert P. Tan, Bruce K. |
| description | Objectives/Hypothesis
Chronic Rhinosinusitis (CRS) is accompanied by evidence of a vigorous adaptive immune response, and emerging studies demonstrate that some nasal polyps manifest a polyclonal autoantibody response. We previously found that antibodies against BP180, a component of the hemidesmosome complex and the dominant epitope in autoimmune bullous pemphigoid, were found at elevated levels in nasal polyp tissue. Given the critical role of hemidesmosomes in maintaining epithelial integrity, we sought to investigate the distribution of BP180 in nasal tissue and evaluate for evidence of systemic autoimmunity against this antigen in CRS.
Study Design
Case‐control experimental study.
Methods
The expression and distribution of BP180 in cultured nasal epithelial cells and normal nasal tissue were confirmed using real‐time polymerase chain reaction (PCR), Western immunoblotting, immunofluorescence and immunohistochemistry. Sera were collected from three groups: control, CRSsNP, and CRSwNP. A commercially available ELISA was utilized to compare anti‐BP180 autoantibody levels in sera.
Results
BP180 is expressed in nasal epithelium, but is not confined to the basement membrane as it is in human skin. In cultured nasal epithelial cells, confocal immunofluorescence showed a punctate distribution of BP180 along the basal surface, consistent with its distribution in epithelial keratinocytes. There are significantly higher levels of circulating nonpathologic anti‐BP180 autoantibodies in CRS patients compared with normal controls (P |
| doi_str_mv | 10.1002/lary.24016 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3813294</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3052312521</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5526-91c502821fb18e1e2f04e32d6969388980e8c5cb063184f5544af0f06dcc11c3</originalsourceid><addsrcrecordid>eNp9kd9LHDEQx4O01FP70j9AFnwRYTWTX5u8CKdWKxxaiqD2JeRy2V50LzmT3bb-9-55elgf-jQM85kPM3wR-gJ4HzAmB41Jj_uEYRBraACcQsmU4h_QoB_SUnJys442cr7DGCrK8Se0ThiISoIcoMNhkWLjijqmwoTWl0ffQeLCdG1ctOM48S4XPhR2mmLwtkhTH2L2ocu-9XkLfaxNk93nl7qJrk6_Xh1_K0eXZ-fHw1FpOSeiVGA5JpJAPQbpwJEaM0fJRCihqJRKYictt2MsKEhWc86YqXGNxcRaAEs30eFSO-_GMzexLrTJNHqe_Kz_XUfj9b-T4Kf6V_ytqQRKFOsFuy-CFB86l1s989m6pjHBxS5rYKwCzIikPbrzDr2LXQr9dz1FKlCqeqb2lpRNMefk6tUxgPUiFb1IRT-n0sPbb89foa8x9AAsgT--cY__UenR8Mftq7Rc7vjcur-rHZPutahoxfX1xZkG_vOEXZMbLegTqwWlZQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1427199783</pqid></control><display><type>article</type><title>A role for anti-BP180 autoantibodies in chronic rhinosinusitis</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Jeffe, Jill S. ; Seshadri, Sudarshan ; Hamill, Kevin J. ; Huang, Julia He ; Carter, Roderick ; Suh, Lydia ; Hulse, Kathryn E. ; Norton, James ; Conley, David B. ; Chandra, Rakesh K. ; Kern, Robert C. ; Jones, Jonathan C. R. ; Schleimer, Robert P. ; Tan, Bruce K.</creator><creatorcontrib>Jeffe, Jill S. ; Seshadri, Sudarshan ; Hamill, Kevin J. ; Huang, Julia He ; Carter, Roderick ; Suh, Lydia ; Hulse, Kathryn E. ; Norton, James ; Conley, David B. ; Chandra, Rakesh K. ; Kern, Robert C. ; Jones, Jonathan C. R. ; Schleimer, Robert P. ; Tan, Bruce K.</creatorcontrib><description>Objectives/Hypothesis
Chronic Rhinosinusitis (CRS) is accompanied by evidence of a vigorous adaptive immune response, and emerging studies demonstrate that some nasal polyps manifest a polyclonal autoantibody response. We previously found that antibodies against BP180, a component of the hemidesmosome complex and the dominant epitope in autoimmune bullous pemphigoid, were found at elevated levels in nasal polyp tissue. Given the critical role of hemidesmosomes in maintaining epithelial integrity, we sought to investigate the distribution of BP180 in nasal tissue and evaluate for evidence of systemic autoimmunity against this antigen in CRS.
Study Design
Case‐control experimental study.
Methods
The expression and distribution of BP180 in cultured nasal epithelial cells and normal nasal tissue were confirmed using real‐time polymerase chain reaction (PCR), Western immunoblotting, immunofluorescence and immunohistochemistry. Sera were collected from three groups: control, CRSsNP, and CRSwNP. A commercially available ELISA was utilized to compare anti‐BP180 autoantibody levels in sera.
Results
BP180 is expressed in nasal epithelium, but is not confined to the basement membrane as it is in human skin. In cultured nasal epithelial cells, confocal immunofluorescence showed a punctate distribution of BP180 along the basal surface, consistent with its distribution in epithelial keratinocytes. There are significantly higher levels of circulating nonpathologic anti‐BP180 autoantibodies in CRS patients compared with normal controls (P <0.05).
Conclusions
BP180 is more widely expressed in nasal epithelium versus skin, although it appears to play a similar role in the formation of hemidesmosomes along the basement membrane. Further investigations are ongoing to characterize the pathogenicity of the anti‐epithelial antibody response in CRS.
Level of Evidence
N/A. Laryngoscope, 123:2104–2111, 2013</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.24016</identifier><identifier>PMID: 24167818</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; autoantibodies ; Autoantibodies - genetics ; Autoantibodies - metabolism ; Autoantigens - genetics ; Autoantigens - metabolism ; autoimmunity ; Blotting, Western ; bullous pemphigoid ; Case-Control Studies ; Cells, Cultured ; Chronic Disease ; Chronic rhinosinusitis ; Collagen Type XVII ; Enzyme-Linked Immunosorbent Assay ; Epithelial Cells - immunology ; Epithelial Cells - metabolism ; Fluorescent Antibody Technique ; Humans ; Immunohistochemistry ; Medical research ; Middle Aged ; Nasal Mucosa - cytology ; Nasal Mucosa - immunology ; Nasal Mucosa - metabolism ; nasal polyps ; Non-Fibrillar Collagens - genetics ; Non-Fibrillar Collagens - metabolism ; Real-Time Polymerase Chain Reaction ; Reference Values ; Rhinitis - blood ; Rhinitis - immunology ; Rhinitis - physiopathology ; Sensitivity and Specificity ; sinusitis ; Sinusitis - blood ; Sinusitis - immunology ; Sinusitis - physiopathology ; Statistics, Nonparametric</subject><ispartof>The Laryngoscope, 2013-09, Vol.123 (9), p.2104-2111</ispartof><rights>Copyright © 2013 The American Laryngological, Rhinological and Otological Society, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5526-91c502821fb18e1e2f04e32d6969388980e8c5cb063184f5544af0f06dcc11c3</citedby><cites>FETCH-LOGICAL-c5526-91c502821fb18e1e2f04e32d6969388980e8c5cb063184f5544af0f06dcc11c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.24016$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.24016$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,782,786,887,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24167818$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeffe, Jill S.</creatorcontrib><creatorcontrib>Seshadri, Sudarshan</creatorcontrib><creatorcontrib>Hamill, Kevin J.</creatorcontrib><creatorcontrib>Huang, Julia He</creatorcontrib><creatorcontrib>Carter, Roderick</creatorcontrib><creatorcontrib>Suh, Lydia</creatorcontrib><creatorcontrib>Hulse, Kathryn E.</creatorcontrib><creatorcontrib>Norton, James</creatorcontrib><creatorcontrib>Conley, David B.</creatorcontrib><creatorcontrib>Chandra, Rakesh K.</creatorcontrib><creatorcontrib>Kern, Robert C.</creatorcontrib><creatorcontrib>Jones, Jonathan C. R.</creatorcontrib><creatorcontrib>Schleimer, Robert P.</creatorcontrib><creatorcontrib>Tan, Bruce K.</creatorcontrib><title>A role for anti-BP180 autoantibodies in chronic rhinosinusitis</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objectives/Hypothesis
Chronic Rhinosinusitis (CRS) is accompanied by evidence of a vigorous adaptive immune response, and emerging studies demonstrate that some nasal polyps manifest a polyclonal autoantibody response. We previously found that antibodies against BP180, a component of the hemidesmosome complex and the dominant epitope in autoimmune bullous pemphigoid, were found at elevated levels in nasal polyp tissue. Given the critical role of hemidesmosomes in maintaining epithelial integrity, we sought to investigate the distribution of BP180 in nasal tissue and evaluate for evidence of systemic autoimmunity against this antigen in CRS.
Study Design
Case‐control experimental study.
Methods
The expression and distribution of BP180 in cultured nasal epithelial cells and normal nasal tissue were confirmed using real‐time polymerase chain reaction (PCR), Western immunoblotting, immunofluorescence and immunohistochemistry. Sera were collected from three groups: control, CRSsNP, and CRSwNP. A commercially available ELISA was utilized to compare anti‐BP180 autoantibody levels in sera.
Results
BP180 is expressed in nasal epithelium, but is not confined to the basement membrane as it is in human skin. In cultured nasal epithelial cells, confocal immunofluorescence showed a punctate distribution of BP180 along the basal surface, consistent with its distribution in epithelial keratinocytes. There are significantly higher levels of circulating nonpathologic anti‐BP180 autoantibodies in CRS patients compared with normal controls (P <0.05).
Conclusions
BP180 is more widely expressed in nasal epithelium versus skin, although it appears to play a similar role in the formation of hemidesmosomes along the basement membrane. Further investigations are ongoing to characterize the pathogenicity of the anti‐epithelial antibody response in CRS.
Level of Evidence
N/A. Laryngoscope, 123:2104–2111, 2013</description><subject>Adult</subject><subject>Aged</subject><subject>autoantibodies</subject><subject>Autoantibodies - genetics</subject><subject>Autoantibodies - metabolism</subject><subject>Autoantigens - genetics</subject><subject>Autoantigens - metabolism</subject><subject>autoimmunity</subject><subject>Blotting, Western</subject><subject>bullous pemphigoid</subject><subject>Case-Control Studies</subject><subject>Cells, Cultured</subject><subject>Chronic Disease</subject><subject>Chronic rhinosinusitis</subject><subject>Collagen Type XVII</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Epithelial Cells - immunology</subject><subject>Epithelial Cells - metabolism</subject><subject>Fluorescent Antibody Technique</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Nasal Mucosa - cytology</subject><subject>Nasal Mucosa - immunology</subject><subject>Nasal Mucosa - metabolism</subject><subject>nasal polyps</subject><subject>Non-Fibrillar Collagens - genetics</subject><subject>Non-Fibrillar Collagens - metabolism</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Reference Values</subject><subject>Rhinitis - blood</subject><subject>Rhinitis - immunology</subject><subject>Rhinitis - physiopathology</subject><subject>Sensitivity and Specificity</subject><subject>sinusitis</subject><subject>Sinusitis - blood</subject><subject>Sinusitis - immunology</subject><subject>Sinusitis - physiopathology</subject><subject>Statistics, Nonparametric</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd9LHDEQx4O01FP70j9AFnwRYTWTX5u8CKdWKxxaiqD2JeRy2V50LzmT3bb-9-55elgf-jQM85kPM3wR-gJ4HzAmB41Jj_uEYRBraACcQsmU4h_QoB_SUnJys442cr7DGCrK8Se0ThiISoIcoMNhkWLjijqmwoTWl0ffQeLCdG1ctOM48S4XPhR2mmLwtkhTH2L2ocu-9XkLfaxNk93nl7qJrk6_Xh1_K0eXZ-fHw1FpOSeiVGA5JpJAPQbpwJEaM0fJRCihqJRKYictt2MsKEhWc86YqXGNxcRaAEs30eFSO-_GMzexLrTJNHqe_Kz_XUfj9b-T4Kf6V_ytqQRKFOsFuy-CFB86l1s989m6pjHBxS5rYKwCzIikPbrzDr2LXQr9dz1FKlCqeqb2lpRNMefk6tUxgPUiFb1IRT-n0sPbb89foa8x9AAsgT--cY__UenR8Mftq7Rc7vjcur-rHZPutahoxfX1xZkG_vOEXZMbLegTqwWlZQ</recordid><startdate>201309</startdate><enddate>201309</enddate><creator>Jeffe, Jill S.</creator><creator>Seshadri, Sudarshan</creator><creator>Hamill, Kevin J.</creator><creator>Huang, Julia He</creator><creator>Carter, Roderick</creator><creator>Suh, Lydia</creator><creator>Hulse, Kathryn E.</creator><creator>Norton, James</creator><creator>Conley, David B.</creator><creator>Chandra, Rakesh K.</creator><creator>Kern, Robert C.</creator><creator>Jones, Jonathan C. R.</creator><creator>Schleimer, Robert P.</creator><creator>Tan, Bruce K.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201309</creationdate><title>A role for anti-BP180 autoantibodies in chronic rhinosinusitis</title><author>Jeffe, Jill S. ; Seshadri, Sudarshan ; Hamill, Kevin J. ; Huang, Julia He ; Carter, Roderick ; Suh, Lydia ; Hulse, Kathryn E. ; Norton, James ; Conley, David B. ; Chandra, Rakesh K. ; Kern, Robert C. ; Jones, Jonathan C. R. ; Schleimer, Robert P. ; Tan, Bruce K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5526-91c502821fb18e1e2f04e32d6969388980e8c5cb063184f5544af0f06dcc11c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>autoantibodies</topic><topic>Autoantibodies - genetics</topic><topic>Autoantibodies - metabolism</topic><topic>Autoantigens - genetics</topic><topic>Autoantigens - metabolism</topic><topic>autoimmunity</topic><topic>Blotting, Western</topic><topic>bullous pemphigoid</topic><topic>Case-Control Studies</topic><topic>Cells, Cultured</topic><topic>Chronic Disease</topic><topic>Chronic rhinosinusitis</topic><topic>Collagen Type XVII</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Epithelial Cells - immunology</topic><topic>Epithelial Cells - metabolism</topic><topic>Fluorescent Antibody Technique</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Nasal Mucosa - cytology</topic><topic>Nasal Mucosa - immunology</topic><topic>Nasal Mucosa - metabolism</topic><topic>nasal polyps</topic><topic>Non-Fibrillar Collagens - genetics</topic><topic>Non-Fibrillar Collagens - metabolism</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Reference Values</topic><topic>Rhinitis - blood</topic><topic>Rhinitis - immunology</topic><topic>Rhinitis - physiopathology</topic><topic>Sensitivity and Specificity</topic><topic>sinusitis</topic><topic>Sinusitis - blood</topic><topic>Sinusitis - immunology</topic><topic>Sinusitis - physiopathology</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeffe, Jill S.</creatorcontrib><creatorcontrib>Seshadri, Sudarshan</creatorcontrib><creatorcontrib>Hamill, Kevin J.</creatorcontrib><creatorcontrib>Huang, Julia He</creatorcontrib><creatorcontrib>Carter, Roderick</creatorcontrib><creatorcontrib>Suh, Lydia</creatorcontrib><creatorcontrib>Hulse, Kathryn E.</creatorcontrib><creatorcontrib>Norton, James</creatorcontrib><creatorcontrib>Conley, David B.</creatorcontrib><creatorcontrib>Chandra, Rakesh K.</creatorcontrib><creatorcontrib>Kern, Robert C.</creatorcontrib><creatorcontrib>Jones, Jonathan C. R.</creatorcontrib><creatorcontrib>Schleimer, Robert P.</creatorcontrib><creatorcontrib>Tan, Bruce K.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeffe, Jill S.</au><au>Seshadri, Sudarshan</au><au>Hamill, Kevin J.</au><au>Huang, Julia He</au><au>Carter, Roderick</au><au>Suh, Lydia</au><au>Hulse, Kathryn E.</au><au>Norton, James</au><au>Conley, David B.</au><au>Chandra, Rakesh K.</au><au>Kern, Robert C.</au><au>Jones, Jonathan C. R.</au><au>Schleimer, Robert P.</au><au>Tan, Bruce K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A role for anti-BP180 autoantibodies in chronic rhinosinusitis</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2013-09</date><risdate>2013</risdate><volume>123</volume><issue>9</issue><spage>2104</spage><epage>2111</epage><pages>2104-2111</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract>Objectives/Hypothesis
Chronic Rhinosinusitis (CRS) is accompanied by evidence of a vigorous adaptive immune response, and emerging studies demonstrate that some nasal polyps manifest a polyclonal autoantibody response. We previously found that antibodies against BP180, a component of the hemidesmosome complex and the dominant epitope in autoimmune bullous pemphigoid, were found at elevated levels in nasal polyp tissue. Given the critical role of hemidesmosomes in maintaining epithelial integrity, we sought to investigate the distribution of BP180 in nasal tissue and evaluate for evidence of systemic autoimmunity against this antigen in CRS.
Study Design
Case‐control experimental study.
Methods
The expression and distribution of BP180 in cultured nasal epithelial cells and normal nasal tissue were confirmed using real‐time polymerase chain reaction (PCR), Western immunoblotting, immunofluorescence and immunohistochemistry. Sera were collected from three groups: control, CRSsNP, and CRSwNP. A commercially available ELISA was utilized to compare anti‐BP180 autoantibody levels in sera.
Results
BP180 is expressed in nasal epithelium, but is not confined to the basement membrane as it is in human skin. In cultured nasal epithelial cells, confocal immunofluorescence showed a punctate distribution of BP180 along the basal surface, consistent with its distribution in epithelial keratinocytes. There are significantly higher levels of circulating nonpathologic anti‐BP180 autoantibodies in CRS patients compared with normal controls (P <0.05).
Conclusions
BP180 is more widely expressed in nasal epithelium versus skin, although it appears to play a similar role in the formation of hemidesmosomes along the basement membrane. Further investigations are ongoing to characterize the pathogenicity of the anti‐epithelial antibody response in CRS.
Level of Evidence
N/A. Laryngoscope, 123:2104–2111, 2013</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24167818</pmid><doi>10.1002/lary.24016</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0023-852X |
| ispartof | The Laryngoscope, 2013-09, Vol.123 (9), p.2104-2111 |
| issn | 0023-852X 1531-4995 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3813294 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Aged autoantibodies Autoantibodies - genetics Autoantibodies - metabolism Autoantigens - genetics Autoantigens - metabolism autoimmunity Blotting, Western bullous pemphigoid Case-Control Studies Cells, Cultured Chronic Disease Chronic rhinosinusitis Collagen Type XVII Enzyme-Linked Immunosorbent Assay Epithelial Cells - immunology Epithelial Cells - metabolism Fluorescent Antibody Technique Humans Immunohistochemistry Medical research Middle Aged Nasal Mucosa - cytology Nasal Mucosa - immunology Nasal Mucosa - metabolism nasal polyps Non-Fibrillar Collagens - genetics Non-Fibrillar Collagens - metabolism Real-Time Polymerase Chain Reaction Reference Values Rhinitis - blood Rhinitis - immunology Rhinitis - physiopathology Sensitivity and Specificity sinusitis Sinusitis - blood Sinusitis - immunology Sinusitis - physiopathology Statistics, Nonparametric |
| title | A role for anti-BP180 autoantibodies in chronic rhinosinusitis |
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