Specific splice variants are associated with Parkinson's disease
ABSTRACT Background Diagnosis of Parkinson's disease (PD) currently relies on assessment of motor symptoms. Recently, sensitive, specific, and readily available splice variant–specific biomarkers were identified in peripheral blood from participants in the Diagnostic and Prognostic Biomarkers i...
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| Veröffentlicht in: | Movement disorders 2013-10, Vol.28 (12), p.1724-1727 |
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| container_title | Movement disorders |
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| creator | Santiago, Jose A. Scherzer, Clemens R. Potashkin, Judith A. |
| description | ABSTRACT
Background
Diagnosis of Parkinson's disease (PD) currently relies on assessment of motor symptoms. Recently, sensitive, specific, and readily available splice variant–specific biomarkers were identified in peripheral blood from participants in the Diagnostic and Prognostic Biomarkers in Parkinson Disease study.
Methods
Here we test for an association between candidate splice variant biomarkers and PD in blood of an independent population of cases and controls nested in the Harvard NeuroDiscovery Center Biomarker Study.
Results
Expression of 7 out of 13 candidate biomarkers was dysregulated in whole cellular blood of patients with PD.
Conclusions
These results support the view that differential expression of a subset of splice‐variant markers in blood is associated with PD. Further evaluation in untreated, de novo patients and at‐risk subjects is warranted. © 2013 International Parkinson and Movement Disorder Society |
| doi_str_mv | 10.1002/mds.25635 |
| format | Article |
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Background
Diagnosis of Parkinson's disease (PD) currently relies on assessment of motor symptoms. Recently, sensitive, specific, and readily available splice variant–specific biomarkers were identified in peripheral blood from participants in the Diagnostic and Prognostic Biomarkers in Parkinson Disease study.
Methods
Here we test for an association between candidate splice variant biomarkers and PD in blood of an independent population of cases and controls nested in the Harvard NeuroDiscovery Center Biomarker Study.
Results
Expression of 7 out of 13 candidate biomarkers was dysregulated in whole cellular blood of patients with PD.
Conclusions
These results support the view that differential expression of a subset of splice‐variant markers in blood is associated with PD. Further evaluation in untreated, de novo patients and at‐risk subjects is warranted. © 2013 International Parkinson and Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.25635</identifier><identifier>PMID: 24108702</identifier><identifier>CODEN: MOVDEA</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Aged ; biomarker ; Biomarkers - blood ; Female ; gene expression ; Humans ; Male ; Middle Aged ; Movement disorders ; neurodegeneration ; Parkinson Disease - blood ; Parkinson Disease - diagnosis ; Parkinson's disease ; Protein Isoforms - blood ; splicing</subject><ispartof>Movement disorders, 2013-10, Vol.28 (12), p.1724-1727</ispartof><rights>2013 Movement Disorder Society</rights><rights>2013 Movement Disorder Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4815-9c1d8c5fa5d013d9979bb642691173307c35f8cd60096bac1ada526fc0244d563</citedby><cites>FETCH-LOGICAL-c4815-9c1d8c5fa5d013d9979bb642691173307c35f8cd60096bac1ada526fc0244d563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.25635$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.25635$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1416,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24108702$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santiago, Jose A.</creatorcontrib><creatorcontrib>Scherzer, Clemens R.</creatorcontrib><creatorcontrib>Potashkin, Judith A.</creatorcontrib><creatorcontrib>Harvard Biomarker Study</creatorcontrib><creatorcontrib>Harvard Biomarker Study</creatorcontrib><title>Specific splice variants are associated with Parkinson's disease</title><title>Movement disorders</title><addtitle>Mov Disord</addtitle><description>ABSTRACT
Background
Diagnosis of Parkinson's disease (PD) currently relies on assessment of motor symptoms. Recently, sensitive, specific, and readily available splice variant–specific biomarkers were identified in peripheral blood from participants in the Diagnostic and Prognostic Biomarkers in Parkinson Disease study.
Methods
Here we test for an association between candidate splice variant biomarkers and PD in blood of an independent population of cases and controls nested in the Harvard NeuroDiscovery Center Biomarker Study.
Results
Expression of 7 out of 13 candidate biomarkers was dysregulated in whole cellular blood of patients with PD.
Conclusions
These results support the view that differential expression of a subset of splice‐variant markers in blood is associated with PD. Further evaluation in untreated, de novo patients and at‐risk subjects is warranted. © 2013 International Parkinson and Movement Disorder Society</description><subject>Aged</subject><subject>biomarker</subject><subject>Biomarkers - blood</subject><subject>Female</subject><subject>gene expression</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>neurodegeneration</subject><subject>Parkinson Disease - blood</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson's disease</subject><subject>Protein Isoforms - blood</subject><subject>splicing</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1vEzEQQC0EoqHlwB9AK3EoHLb1-NsXBApQkEo_VFCPlmN7qctmN_VsWvrv2TRtBEicfPCbpxk9Ql4A3QNK2f484h6TistHZAKSQ22Y1I_JhBojaw5GbpFniJeUAkhQT8kWE0CNpmxC3p0tUshNDhUu2hxSde1L9t2AlS-p8oh9yH5IsbrJw0V14svP3GHf7WIVMyaPaYc8aXyL6fn9u02-f_r4bfq5Pjw--DJ9f1gHYUDWNkA0QTZeRgo8WqvtbKYEUxZAc0514LIxISpKrZr5AD56yVQTKBMijrdtk7dr72I5m6cYUjcU37pFyXNfbl3vs_v7p8sX7kd_7bgBxs1K8PpeUPqrZcLBzTOG1La-S_0SHQihgUoBdkRf_YNe9svSjeetKGGNAqlH6s2aCqVHLKnZLAPUrbq4sYu76zKyL__cfkM-hBiB_TVwk9t0-3-T-_rh7EFZrycyDunXZmIs5JTmWrrzowNnp-dTpeHUWf4bVRSliw</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Santiago, Jose A.</creator><creator>Scherzer, Clemens R.</creator><creator>Potashkin, Judith A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201310</creationdate><title>Specific splice variants are associated with Parkinson's disease</title><author>Santiago, Jose A. ; Scherzer, Clemens R. ; Potashkin, Judith A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4815-9c1d8c5fa5d013d9979bb642691173307c35f8cd60096bac1ada526fc0244d563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>biomarker</topic><topic>Biomarkers - blood</topic><topic>Female</topic><topic>gene expression</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Movement disorders</topic><topic>neurodegeneration</topic><topic>Parkinson Disease - blood</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson's disease</topic><topic>Protein Isoforms - blood</topic><topic>splicing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santiago, Jose A.</creatorcontrib><creatorcontrib>Scherzer, Clemens R.</creatorcontrib><creatorcontrib>Potashkin, Judith A.</creatorcontrib><creatorcontrib>Harvard Biomarker Study</creatorcontrib><creatorcontrib>Harvard Biomarker Study</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santiago, Jose A.</au><au>Scherzer, Clemens R.</au><au>Potashkin, Judith A.</au><aucorp>Harvard Biomarker Study</aucorp><aucorp>Harvard Biomarker Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specific splice variants are associated with Parkinson's disease</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov Disord</addtitle><date>2013-10</date><risdate>2013</risdate><volume>28</volume><issue>12</issue><spage>1724</spage><epage>1727</epage><pages>1724-1727</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><coden>MOVDEA</coden><abstract>ABSTRACT
Background
Diagnosis of Parkinson's disease (PD) currently relies on assessment of motor symptoms. Recently, sensitive, specific, and readily available splice variant–specific biomarkers were identified in peripheral blood from participants in the Diagnostic and Prognostic Biomarkers in Parkinson Disease study.
Methods
Here we test for an association between candidate splice variant biomarkers and PD in blood of an independent population of cases and controls nested in the Harvard NeuroDiscovery Center Biomarker Study.
Results
Expression of 7 out of 13 candidate biomarkers was dysregulated in whole cellular blood of patients with PD.
Conclusions
These results support the view that differential expression of a subset of splice‐variant markers in blood is associated with PD. Further evaluation in untreated, de novo patients and at‐risk subjects is warranted. © 2013 International Parkinson and Movement Disorder Society</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24108702</pmid><doi>10.1002/mds.25635</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0885-3185 |
| ispartof | Movement disorders, 2013-10, Vol.28 (12), p.1724-1727 |
| issn | 0885-3185 1531-8257 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged biomarker Biomarkers - blood Female gene expression Humans Male Middle Aged Movement disorders neurodegeneration Parkinson Disease - blood Parkinson Disease - diagnosis Parkinson's disease Protein Isoforms - blood splicing |
| title | Specific splice variants are associated with Parkinson's disease |
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