Porins Increase Copper Susceptibility of Mycobacterium tuberculosis

Copper resistance mechanisms are crucial for many pathogenic bacteria, including Mycobacterium tuberculosis, during infection because the innate immune system utilizes copper ions to kill bacterial intruders. Despite several studies detailing responses of mycobacteria to copper, the pathways by whic...

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Veröffentlicht in:	Journal of Bacteriology 2013-11, Vol.195 (22), p.5133-5140
Hauptverfasser:	Speer, Alexander, Rowland, Jennifer L, Haeili, Mehri, Niederweis, Michael, Wolschendorf, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriology Copper Copper - toxicity copper metabolism Gene Expression Genes Gram-negative bacteria Immune system innate immunity Membranes Microbial Sensitivity Tests Mycobacterium smegmatis Mycobacterium smegmatis - drug effects Mycobacterium smegmatis - genetics Mycobacterium smegmatis - growth & development Mycobacterium smegmatis - metabolism Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - metabolism porins Porins - genetics Porins - metabolism Proteins Recombinant Proteins - genetics Recombinant Proteins - metabolism resistance mechanisms spermine
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