Polo‐like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma

Cholangiocarcinoma (CCA) cells paradoxically express the death ligand tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) and thus rely on potent survival signals to circumvent cell death by TRAIL. Hedgehog (Hh) signaling is an important survival pathway in CCA. Herein, we further examin...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2013-10, Vol.58 (4), p.1362-1374
Hauptverfasser:	Fingas, Christian D., Mertens, Joachim C., Razumilava, Nataliya, Sydor, Svenja, Bronk, Steven F., Christensen, John D., Rizvi, Sumera H., Canbay, Ali, Treckmann, Jürgen W., Paul, Andreas, Sirica, Alphonse E., Gores, Gregory J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology Bile Duct Neoplasms - pathology Bile Duct Neoplasms - physiopathology Bile Ducts, Intrahepatic Cell division Cell Line, Tumor Cell Survival - physiology Cholangiocarcinoma - pathology Cholangiocarcinoma - physiopathology Disease Models, Animal Enzyme Inhibitors - pharmacology Hedgehog Proteins - physiology Hepatology Heterografts Humans Kinases Ligands Male Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - drug effects Protein Serine-Threonine Kinases - physiology Proteins Pteridines - pharmacology Rats Rats, Inbred F344 Signal Transduction - physiology TNF-Related Apoptosis-Inducing Ligand - physiology
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