Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation

An 11.7‐Å‐resolution cryo‐EM map of the yeast 80S·eEF2 complex in the presence of the antibiotic sordarin was interpreted in molecular terms, revealing large conformational changes within eEF2 and the 80S ribosome, including a rearrangement of the functionally important ribosomal intersubunit bridge...

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Veröffentlicht in:	The EMBO journal 2004-03, Vol.23 (5), p.1008-1019
Hauptverfasser:	Spahn, Christian MT, Gomez-Lorenzo, Maria G, Grassucci, Robert A, Jørgensen, Rene, Andersen, Gregers R, Beckmann, Roland, Penczek, Pawel A, Ballesta, Juan PG, Frank, Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	80S ribosome Antifungal Agents - pharmacology cryo-EM Cryoelectron Microscopy Crystallography, X-Ray E coli eEF2 elongation factor eEF2 EMBO40 Escherichia coli Indenes Models, Molecular Movement Nucleic Acid Conformation Peptide Elongation Factor 2 - chemistry Peptide Elongation Factor 2 - metabolism Peptide Elongation Factor 2 - ultrastructure Protein Binding Protein Structure, Quaternary Protein Structure, Tertiary Protein Subunits - genetics Protein Subunits - metabolism Ribosomes - chemistry Ribosomes - metabolism Ribosomes - ultrastructure RNA Transport RNA, Transfer - chemistry RNA, Transfer - genetics RNA, Transfer - metabolism Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae - ultrastructure sordarin Translocation tRNA translocation Yeasts
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