CpG island chromatin is shaped by recruitment of ZF-CxxC proteins

Most mammalian gene promoters are embedded within genomic regions called CpG islands, characterized by elevated levels of nonmethylated CpG dinucleotides. Here, we describe recent work demonstrating that CpG islands act as specific nucleation sites for the zinc finger CxxC domain-containing proteins...

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Veröffentlicht in:	Cold Spring Harbor perspectives in biology 2013-11, Vol.5 (11), p.a018648-a018648
Hauptverfasser:	Blackledge, Neil P, Thomson, John P, Skene, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatin - metabolism CpG Islands DNA Methylation Genomics Jumonji Domain-Containing Histone Demethylases - metabolism Mice Models, Genetic Promoter Regions, Genetic Protein Binding Protein Structure, Tertiary Reflection Trans-Activators - metabolism
Online-Zugang:	Volltext
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