Application of systems biology principles to protein biomarker discovery: Urinary exosomal proteome in renal transplantation

Purpose In mass spectrometry (MS)‐based studies to discover urinary protein biomarkers, an important question is how to analyze the data to find the most promising potential biomarkers to be advanced to large‐scale validation studies. Here, we describe a “systems biology‐based” approach to address t...

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Veröffentlicht in:	Proteomics. Clinical applications 2012-06, Vol.6 (5-6), p.268-278
Hauptverfasser:	Pisitkun, Trairak, Gandolfo, Maria T., Das, Samarjit, Knepper, Mark A., Bagnasco, Serena M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bioinformatics Biological and medical sciences Biomarkers Biomarkers - urine Biopsy Chromatography Chromatography, Liquid Data processing Differentiation Diverse techniques Epithelial cells Exosome exosomes Exosomes - metabolism Fundamental and applied biological sciences. Psychology Genomes Graft rejection Humans Immune response Inflammation Injuries Kidney - chemistry Kidney - pathology Kidney Transplantation Mass Spectrometry Mass spectroscopy Molecular and cellular biology Principles Proteins Proteome - analysis Proteomics Rejection Sodium Systems Biology Therapeutic applications Transplant Urine
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