NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells

Most head and neck squamous cell carcinomas (HNSCCs) overexpress epidermal growth factor receptor (EGFR) and EGFR inhibitors are routinely used in the treatment of HNSCC. However, many HNSCC tumors do not respond or become refractory to EGFR inhibitors. Autophagy, which is a stress-induced cellular...

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Veröffentlicht in:	Toxicology and applied pharmacology 2013-11, Vol.272 (3), p.736-745
Hauptverfasser:	Sobhakumari, Arya, Schickling, Brandon M., Love-Homan, Laurie, Raeburn, Ayanna, Fletcher, Elise V.M., Case, Adam J., Domann, Frederick E., Miller, Francis J., Simons, Andrean L.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Autophagy Autophagy - drug effects Autophagy - physiology Biological and medical sciences Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - metabolism CARCINOMAS CATALASE CHEMOTHERAPY Cytoprotection - drug effects Cytoprotection - physiology EGFR ErbB Receptors - antagonists & inhibitors ErbB Receptors - metabolism Erlotinib Erlotinib Hydrochloride GENES GROWTH FACTORS HEAD Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - enzymology Head and Neck Neoplasms - metabolism HEK293 Cells HNSCC Humans LC3B LUCIFERASE Medical sciences MESSENGER-RNA Multiple tumors. Solid tumors. Tumors in childhood (general aspects) NADPH Oxidase 4 NADPH Oxidases - physiology NECK NOX4 Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology OXYGEN Quinazolines - pharmacology Quinazolines - therapeutic use RECEPTORS Squamous Cell Carcinoma of Head and Neck TOXICITY Toxicology Tumor Cells, Cultured Tumors
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