Identification of germline genomic copy number variation in familial pancreatic cancer

Adenocarcinoma of the pancreas is a significant cause of cancer mortality, and up to 10 % of cases appear to be familial. Heritable genomic copy number variants (CNVs) can modulate gene expression and predispose to disease. Here, we identify candidate predisposition genes for familial pancreatic can...

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Veröffentlicht in:	Human genetics 2012-09, Vol.131 (9), p.1481-1494
Hauptverfasser:	Al-Sukhni, Wigdan, Joe, Sarah, Lionel, Anath C., Zwingerman, Nora, Zogopoulos, George, Marshall, Christian R., Borgida, Ayelet, Holter, Spring, Gropper, Aaron, Moore, Sara, Bondy, Melissa, Klein, Alison P., Petersen, Gloria M., Rabe, Kari G., Schwartz, Ann G., Syngal, Sapna, Scherer, Stephen W., Gallinger, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - genetics Algorithms Analysis Biomedical and Life Sciences Biomedicine Cancer Case-Control Studies Computer applications copy number Gene Dosage Gene expression Gene Function Genetic aspects genomics Germ Cells Health aspects Human Genetics Humans Metabolic Diseases Molecular Medicine Mortality Original Investigation Pancreatic cancer Pancreatic Neoplasms - genetics Polymerase Chain Reaction Risk groups
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