Humoral Immunity in Humanized Mice: A Work in Progress
Humanized mice historically have not been good models of human humoral immunity induced by either infection or immunization. However, newer versions of humanized mice generated in severely immunodeficient mice with a targeted disruption of the IL2Rγ c gene have recently been reported to produce anti...
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| Veröffentlicht in: | The Journal of infectious diseases 2013-11, Vol.208 (suppl 2), p.S155-S159 |
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| container_end_page | S159 |
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| container_issue | suppl 2 |
| container_start_page | S155 |
| container_title | The Journal of infectious diseases |
| container_volume | 208 |
| creator | Seung, Edward Tager, Andrew M. |
| description | Humanized mice historically have not been good models of human humoral immunity induced by either infection or immunization. However, newer versions of humanized mice generated in severely immunodeficient mice with a targeted disruption of the IL2Rγ c gene have recently been reported to produce antigen-specific class-switched human antibodies, with some demonstrating neutralizing activities. Here we review the growing ability of humanized mice to support the study of human humoral immune responses, discussing the current and future potential of these models as well as their current limitations. |
| doi_str_mv | 10.1093/infdis/jit448 |
| format | Article |
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However, newer versions of humanized mice generated in severely immunodeficient mice with a targeted disruption of the IL2Rγ c gene have recently been reported to produce antigen-specific class-switched human antibodies, with some demonstrating neutralizing activities. Here we review the growing ability of humanized mice to support the study of human humoral immune responses, discussing the current and future potential of these models as well as their current limitations.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jit448</identifier><identifier>PMID: 24151323</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Antibodies ; B lymphocytes ; Biological and medical sciences ; Blood ; Disease models ; Fundamental and applied biological sciences. Psychology ; Humans ; Humoral immunity ; Immune system ; Immunity, Humoral ; Infections ; Infectious diseases ; Medical sciences ; Mice ; Mice, SCID ; Microbiology ; Models, Animal ; Recent Advances in Humanized Mice: Accelerating the Development of an HIV Vaccine ; T lymphocytes ; Viruses</subject><ispartof>The Journal of infectious diseases, 2013-11, Vol.208 (suppl 2), p.S155-S159</ispartof><rights>2014 INIST-CNRS</rights><rights>The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. 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However, newer versions of humanized mice generated in severely immunodeficient mice with a targeted disruption of the IL2Rγ c gene have recently been reported to produce antigen-specific class-switched human antibodies, with some demonstrating neutralizing activities. Here we review the growing ability of humanized mice to support the study of human humoral immune responses, discussing the current and future potential of these models as well as their current limitations.</description><subject>Animals</subject><subject>Antibodies</subject><subject>B lymphocytes</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Disease models</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Humoral immunity</subject><subject>Immune system</subject><subject>Immunity, Humoral</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, SCID</subject><subject>Microbiology</subject><subject>Models, Animal</subject><subject>Recent Advances in Humanized Mice: Accelerating the Development of an HIV Vaccine</subject><subject>T lymphocytes</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLHUEQhZugxKvJMsuE2QhuJvb74UIQ8QWKWSRk2fTtqTF9MzOt3TOC_npb5npJVq4K6nx1qKqD0BeCvxNs2GEY2ibkw1UYOdcf0IIIpmopCdtCC4wprYk2Zgft5rzCGHMm1Ue0QzkRhFG2QPJy6mNyXXXV99MQxqcqDFXpuSE8Q1PdBA9H1Un1O6a_r8qPFO8S5PwJbbeuy_B5XffQr_Ozn6eX9fXtxdXpyXXtBdNj3fBWtw3j3hPNjMMASy4pUUsHILwmbuk8N8qB19yLphUOuG8oJYYKClixPXQ8-95Pyx4aD8NYlrX3KfQuPdnogv1fGcIfexcfLdNYGSWKwcHaIMWHCfJo-5A9dJ0bIE7ZEim41JiVd7yLcq4I1lqxgtYz6lPMOUG72Yhg-xqLnWOxcyyF__bvGRv6LYcC7K8Bl73r2uQGX8Y3nDKUaCUL93XmVnmMaaNzKqSRVLAXLdahjQ</recordid><startdate>20131115</startdate><enddate>20131115</enddate><creator>Seung, Edward</creator><creator>Tager, Andrew M.</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20131115</creationdate><title>Humoral Immunity in Humanized Mice: A Work in Progress</title><author>Seung, Edward ; Tager, Andrew M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-d4f8fd34cc1839a0eeb46217baee5c81abac497aec84c5df5ae4cd2219252e073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>B lymphocytes</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Disease models</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Humoral immunity</topic><topic>Immune system</topic><topic>Immunity, Humoral</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, SCID</topic><topic>Microbiology</topic><topic>Models, Animal</topic><topic>Recent Advances in Humanized Mice: Accelerating the Development of an HIV Vaccine</topic><topic>T lymphocytes</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seung, Edward</creatorcontrib><creatorcontrib>Tager, Andrew M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seung, Edward</au><au>Tager, Andrew M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Humoral Immunity in Humanized Mice: A Work in Progress</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2013-11-15</date><risdate>2013</risdate><volume>208</volume><issue>suppl 2</issue><spage>S155</spage><epage>S159</epage><pages>S155-S159</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Humanized mice historically have not been good models of human humoral immunity induced by either infection or immunization. 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| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2013-11, Vol.208 (suppl 2), p.S155-S159 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Antibodies B lymphocytes Biological and medical sciences Blood Disease models Fundamental and applied biological sciences. Psychology Humans Humoral immunity Immune system Immunity, Humoral Infections Infectious diseases Medical sciences Mice Mice, SCID Microbiology Models, Animal Recent Advances in Humanized Mice: Accelerating the Development of an HIV Vaccine T lymphocytes Viruses |
| title | Humoral Immunity in Humanized Mice: A Work in Progress |
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