Amyloid Deposition and Cognition in Older Adults: The Effects of Premorbid Intellect
Although amyloid deposition remains a marker of the development of Alzheimer's disease, results linking amyloid and cognition have been equivocal. Twenty-five community-dwelling non-demented older adults were examined with (18)F-flutemetamol, an amyloid imaging agent, and a cognitive battery, i...
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| Veröffentlicht in: | Archives of clinical neuropsychology 2013-11, Vol.28 (7), p.665-671 |
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| creator | DUFF, Kevin FOSTER, Norman L HOFFMAN, John M DENNETT, Kathryn HAMMERS, Dustin B ZOLLINGER, Lauren V CHRISTIAN, Paul E BUTTERFIELD, Regan I BEARDMORE, Britney E WANG, Angela Y MORTON, Kathryn A |
| description | Although amyloid deposition remains a marker of the development of Alzheimer's disease, results linking amyloid and cognition have been equivocal. Twenty-five community-dwelling non-demented older adults were examined with (18)F-flutemetamol, an amyloid imaging agent, and a cognitive battery, including an estimate of premorbid intellect and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). In the first model, (18)F-flutemetamol uptake significantly correlated with the Delayed Memory Index of the RBANS (r = -.51, p = .02) and premorbid intellect (r = .43, p = .03). In the second model, the relationship between (18)F-flutemetamol and cognition was notably stronger when controlling for premorbid intellect (e.g., three of the five RBANS Indexes and its Total score significantly correlated with (18)F-flutemetamol, r's = -.41 to -.58). Associations were found between amyloid-binding (18)F-flutemetamol and cognitive functioning in non-demented older adults. These associations were greatest with delayed memory and stronger when premorbid intellect was considered, suggesting that cognitive reserve partly compensates for the symptomatic expression of amyloid pathology in community-dwelling elderly. |
| doi_str_mv | 10.1093/arclin/act047 |
| format | Article |
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Twenty-five community-dwelling non-demented older adults were examined with (18)F-flutemetamol, an amyloid imaging agent, and a cognitive battery, including an estimate of premorbid intellect and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). In the first model, (18)F-flutemetamol uptake significantly correlated with the Delayed Memory Index of the RBANS (r = -.51, p = .02) and premorbid intellect (r = .43, p = .03). In the second model, the relationship between (18)F-flutemetamol and cognition was notably stronger when controlling for premorbid intellect (e.g., three of the five RBANS Indexes and its Total score significantly correlated with (18)F-flutemetamol, r's = -.41 to -.58). Associations were found between amyloid-binding (18)F-flutemetamol and cognitive functioning in non-demented older adults. These associations were greatest with delayed memory and stronger when premorbid intellect was considered, suggesting that cognitive reserve partly compensates for the symptomatic expression of amyloid pathology in community-dwelling elderly.</description><identifier>ISSN: 0887-6177</identifier><identifier>EISSN: 1873-5843</identifier><identifier>DOI: 10.1093/arclin/act047</identifier><identifier>PMID: 23817438</identifier><identifier>CODEN: ACNEET</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult and adolescent clinical studies ; Aged ; Aged, 80 and over ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - metabolism ; Alzheimer Disease - pathology ; Amyloid - metabolism ; Biological and medical sciences ; Brain - diagnostic imaging ; Brain - metabolism ; Brain - pathology ; Cognition - physiology ; Cognition Disorders - diagnostic imaging ; Cognition Disorders - metabolism ; Cognition Disorders - pathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Humans ; Male ; Medical sciences ; Neurology ; Neuropsychological Tests ; Organic mental disorders. Neuropsychology ; Original Empirical ; Positron-Emission Tomography ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry</subject><ispartof>Archives of clinical neuropsychology, 2013-11, Vol.28 (7), p.665-671</ispartof><rights>2015 INIST-CNRS</rights><rights>The Author 2013. Published by Oxford University Press. All rights reserved. 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Twenty-five community-dwelling non-demented older adults were examined with (18)F-flutemetamol, an amyloid imaging agent, and a cognitive battery, including an estimate of premorbid intellect and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). In the first model, (18)F-flutemetamol uptake significantly correlated with the Delayed Memory Index of the RBANS (r = -.51, p = .02) and premorbid intellect (r = .43, p = .03). In the second model, the relationship between (18)F-flutemetamol and cognition was notably stronger when controlling for premorbid intellect (e.g., three of the five RBANS Indexes and its Total score significantly correlated with (18)F-flutemetamol, r's = -.41 to -.58). Associations were found between amyloid-binding (18)F-flutemetamol and cognitive functioning in non-demented older adults. These associations were greatest with delayed memory and stronger when premorbid intellect was considered, suggesting that cognitive reserve partly compensates for the symptomatic expression of amyloid pathology in community-dwelling elderly.</description><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - pathology</subject><subject>Amyloid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Cognition - physiology</subject><subject>Cognition Disorders - diagnostic imaging</subject><subject>Cognition Disorders - metabolism</subject><subject>Cognition Disorders - pathology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Original Empirical</subject><subject>Positron-Emission Tomography</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Original Empirical</topic><topic>Positron-Emission Tomography</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DUFF, Kevin</creatorcontrib><creatorcontrib>FOSTER, Norman L</creatorcontrib><creatorcontrib>HOFFMAN, John M</creatorcontrib><creatorcontrib>DENNETT, Kathryn</creatorcontrib><creatorcontrib>HAMMERS, Dustin B</creatorcontrib><creatorcontrib>ZOLLINGER, Lauren V</creatorcontrib><creatorcontrib>CHRISTIAN, Paul E</creatorcontrib><creatorcontrib>BUTTERFIELD, Regan I</creatorcontrib><creatorcontrib>BEARDMORE, Britney E</creatorcontrib><creatorcontrib>WANG, Angela Y</creatorcontrib><creatorcontrib>MORTON, Kathryn A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of clinical neuropsychology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DUFF, Kevin</au><au>FOSTER, Norman L</au><au>HOFFMAN, John M</au><au>DENNETT, Kathryn</au><au>HAMMERS, Dustin B</au><au>ZOLLINGER, Lauren V</au><au>CHRISTIAN, Paul E</au><au>BUTTERFIELD, Regan I</au><au>BEARDMORE, Britney E</au><au>WANG, Angela Y</au><au>MORTON, Kathryn A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amyloid Deposition and Cognition in Older Adults: The Effects of Premorbid Intellect</atitle><jtitle>Archives of clinical neuropsychology</jtitle><addtitle>Arch Clin Neuropsychol</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>28</volume><issue>7</issue><spage>665</spage><epage>671</epage><pages>665-671</pages><issn>0887-6177</issn><eissn>1873-5843</eissn><coden>ACNEET</coden><abstract>Although amyloid deposition remains a marker of the development of Alzheimer's disease, results linking amyloid and cognition have been equivocal. Twenty-five community-dwelling non-demented older adults were examined with (18)F-flutemetamol, an amyloid imaging agent, and a cognitive battery, including an estimate of premorbid intellect and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). In the first model, (18)F-flutemetamol uptake significantly correlated with the Delayed Memory Index of the RBANS (r = -.51, p = .02) and premorbid intellect (r = .43, p = .03). In the second model, the relationship between (18)F-flutemetamol and cognition was notably stronger when controlling for premorbid intellect (e.g., three of the five RBANS Indexes and its Total score significantly correlated with (18)F-flutemetamol, r's = -.41 to -.58). Associations were found between amyloid-binding (18)F-flutemetamol and cognitive functioning in non-demented older adults. These associations were greatest with delayed memory and stronger when premorbid intellect was considered, suggesting that cognitive reserve partly compensates for the symptomatic expression of amyloid pathology in community-dwelling elderly.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>23817438</pmid><doi>10.1093/arclin/act047</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of clinical neuropsychology, 2013-11, Vol.28 (7), p.665-671 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult and adolescent clinical studies Aged Aged, 80 and over Alzheimer Disease - diagnostic imaging Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid - metabolism Biological and medical sciences Brain - diagnostic imaging Brain - metabolism Brain - pathology Cognition - physiology Cognition Disorders - diagnostic imaging Cognition Disorders - metabolism Cognition Disorders - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Male Medical sciences Neurology Neuropsychological Tests Organic mental disorders. Neuropsychology Original Empirical Positron-Emission Tomography Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry |
| title | Amyloid Deposition and Cognition in Older Adults: The Effects of Premorbid Intellect |
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