Human Cytomegalovirus IE1 Protein Disrupts Interleukin-6 Signaling by Sequestering STAT3 in the Nucleus

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Veröffentlicht in:	Journal of Virology 2013-10, Vol.87 (19), p.10763-10776
Hauptverfasser:	Reitsma, Justin M, Sato, Hiromi, Nevels, Michael, Terhune, Scott S, Paulus, Christina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytoma - metabolism Astrocytoma - pathology Astrocytoma - virology Blotting, Western Cell Nucleus - genetics Cell Nucleus - metabolism Cells, Cultured Cytomegalovirus - physiology Cytomegalovirus Infections - genetics Cytomegalovirus Infections - metabolism Cytomegalovirus Infections - virology Fibroblasts - cytology Fibroblasts - metabolism Fibroblasts - virology Fluorescent Antibody Technique Human cytomegalovirus Humans Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Interleukin-6 - genetics Interleukin-6 - metabolism Mice Phosphorylation Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Signal Transduction STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Trans-Activators Virus Replication Virus-Cell Interactions
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