Immunization with DNA Vaccines Encoding Glycoprotein D or Glycoprotein B, Alone or in Combination, Induces Protective Immunity in Animal Models of Herpes Simplex Virus-2 Disease

DNA vaccines expressing herpes simplex virus type 2 (HSV-2) full-length glycoprotein D (gD), or a truncated form of HSV-2 glycoprotein B (gB) were evaluated for protective efficacy in two experimental models of HSV-2 infection. Intramuscular (i.m.) injection of mice showed that each construction ind...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-10, Vol.93 (21), p.11414-11420
Hauptverfasser:	McClements, William L., Armstrong, Marcy E., Keys, Robert D., Liu, Margaret A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies Antibodies, Viral - biosynthesis Antibody Formation Cell Line Cercopithecus aethiops Deoxyribonucleic acid Disease models DNA DNA, Viral - immunology Dosage Glycoproteins Guinea Pigs Herpes Genitalis - immunology Herpes Genitalis - prevention & control herpes simplex virus 2 Herpes viruses Herpesvirus 2, Human - genetics Herpesvirus 2, Human - immunology Human herpesvirus 2 Humans Immunization Infections Kidney Mice Papers from a Colloquium Proteins Vaccination Vaccines Vaccines, Synthetic Vero Cells Viral Envelope Proteins - biosynthesis Viral Envelope Proteins - immunology Viral Vaccines Viruses
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