Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

Recognition of injured mitochondria for degradation by macroautophagy is essential for cellular health, but the mechanisms remain poorly understood. Cardiolipin is an inner mitochondrial membrane phospholipid. We found that rotenone, staurosporine, 6-hydroxydopamine and other pro-mitophagy stimuli c...

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Veröffentlicht in:	Nature cell biology 2013-10, Vol.15 (10), p.1197-1205
Hauptverfasser:	Chu, Charleen T., Ji, Jing, Dagda, Ruben K., Jiang, Jian Fei, Tyurina, Yulia Y., Kapralov, Alexandr A., Tyurin, Vladimir A., Yanamala, Naveena, Shrivastava, Indira H., Mohammadyani, Dariush, Qiang Wang, Kent Zhi, Zhu, Jianhui, Klein-Seetharaman, Judith, Balasubramanian, Krishnakumar, Amoscato, Andrew A., Borisenko, Grigory, Huang, Zhentai, Gusdon, Aaron M., Cheikhi, Amin, Steer, Erin K., Wang, Ruth, Baty, Catherine, Watkins, Simon, Bahar, Ivet, Bayır, Hülya, Kagan, Valerian E.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/39 631/80/39/2348 Amino Acid Sequence Animals Autophagy Autophagy - drug effects Biological Transport - drug effects Biology Cancer Research Cardiolipin Cardiolipins - genetics Cardiolipins - metabolism Cell Biology Cell Line, Tumor Cells, Cultured Developmental Biology Gene Knockdown Techniques HeLa Cells Humans Life Sciences Localization Membranes Mitochondria Mitochondria - drug effects Mitochondrial Membranes - metabolism Mitophagy - drug effects Mitophagy - physiology Models, Molecular Molecular Sequence Data Mutation Neurons Neurons - drug effects Neurons - physiology Oxidopamine - pharmacology Physiological aspects Protein Structure, Tertiary Proteins Rats Rats, Sprague-Dawley Rotenone Rotenone - pharmacology Signal Transduction Stem Cells Uncoupling Agents - pharmacology
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