Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors

Small-molecule inhibitors that block the MDM2-p53 protein–protein interaction (MDM2 inhibitors) are being intensely pursued as a new therapeutic strategy for cancer treatment. We previously published a series of spirooxindole-containing compounds as a new class of MDM2 small-molecule inhibitors. We...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 2013-05, Vol.135 (19), p.7223-7234
Hauptverfasser:	Zhao, Yujun, Liu, Liu, Sun, Wei, Lu, Jianfeng, McEachern, Donna, Li, Xiaoqin, Yu, Shanghai, Bernard, Denzil, Ochsenbein, Philippe, Ferey, Vincent, Carry, Jean-Christophe, Deschamps, Jeffrey R, Sun, Duxin, Wang, Shaomeng
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use binding capacity Bone and Bones - drug effects Bone and Bones - metabolism Bone and Bones - pathology Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell Line, Tumor Cyclization diastereomers Humans Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacokinetics Indoles - therapeutic use Mice, SCID Models, Molecular neoplasms Osteosarcoma - drug therapy Osteosarcoma - metabolism Osteosarcoma - pathology protein-protein interactions Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors Proto-Oncogene Proteins c-mdm2 - metabolism remission Spiro Compounds - chemical synthesis Spiro Compounds - chemistry Spiro Compounds - pharmacokinetics Spiro Compounds - therapeutic use stereochemistry Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!