Emerging Paradigms in the Development of Resistance to Tyrosine Kinase Inhibitors in Lung Cancer

The success of tyrosine kinase inhibitors (TKIs) in select patients with non-small-cell lung cancer (NSCLC) has transformed management of the disease, placing new emphasis on understanding the molecular characteristics of tumor specimens. It is now recognized that genetic alterations in the epiderma...

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Veröffentlicht in:	Journal of clinical oncology 2013-11, Vol.31 (31), p.3987-3996
Hauptverfasser:	GAINOR, Justin F, SHAW, Alice T
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biology of Neoplasia Bon Drug Resistance, Neoplasm - physiology Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - physiopathology Medical sciences Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Pneumology Protein Kinase Inhibitors - therapeutic use Protein-Tyrosine Kinases - antagonists & inhibitors Tumors Tumors of the respiratory system and mediastinum
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