Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin

TLRs play a central role in the innate recognition of pathogens and the activation of dendritic cells (DCs). In this study, we establish that, in addition to TLR11, TLR12 recognizes the profilin protein of the protozoan parasite Toxoplasma gondii and regulates IL-12 production by DCs in response to...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-11, Vol.191 (9), p.4818-4827
Hauptverfasser:	Raetz, Megan, Kibardin, Alexey, Sturge, Carolyn R, Pifer, Reed, Li, Haiying, Burstein, Ezra, Ozato, Keiko, Larin, Sergey, Yarovinsky, Felix
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Protozoan - immunology CD8 Antigens - metabolism Cell Line Dendritic Cells - immunology HEK293 Cells Humans Interferon Regulatory Factors - metabolism Interleukin-12 - biosynthesis Interleukin-12 - metabolism Membrane Transport Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Myeloid Differentiation Factor 88 - genetics NF-kappa B - metabolism Profilins - immunology Profilins - metabolism Protein Binding - immunology RNA Interference RNA, Small Interfering Signal Transduction - immunology Toll-Like Receptors - genetics Toll-Like Receptors - metabolism Toxoplasma - immunology Toxoplasma - metabolism Toxoplasma gondii Toxoplasmosis, Animal - immunology Toxoplasmosis, Animal - metabolism Toxoplasmosis, Animal - parasitology
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