Mesenchymal stem cells in ex vivo cord blood expansion
Umbilical cord blood (CB) is becoming an important source of haematopoietic support for transplant patients lacking human leukocyte antigen matched donors. The ethnic diversity, relative ease of collection, ready availability as cryopreserved units from CB banks, reduced incidence and severity of gr...
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| Veröffentlicht in: | Best practice & research. Clinical haematology 2011-03, Vol.24 (1), p.83-92 |
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| container_title | Best practice & research. Clinical haematology |
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| creator | Robinson, Simon N., Ph.D Simmons, Paul J., Ph.D Yang, Hong, Ph.D., MD Alousi, Amin M., MD Marcos de Lima, J., MD Shpall, Elizabeth J., MD |
| description | Umbilical cord blood (CB) is becoming an important source of haematopoietic support for transplant patients lacking human leukocyte antigen matched donors. The ethnic diversity, relative ease of collection, ready availability as cryopreserved units from CB banks, reduced incidence and severity of graft versus host disease and tolerance of higher degrees of HLA disparity between donor and recipient, are positive attributes when compared to bone marrow or cytokine-mobilized peripheral blood. However, CB transplantation is associated with significantly delayed neutrophil and platelet engraftment and an elevated risk of graft failure. These hurdles are thought to be due, at least in part, to low total nucleated cell and CD34+ cell doses transplanted. Here, current strategies directed at improving TNC and CD34+ cell doses at transplant are discussed, with particular attention paid to the use of a mesenchymal stem cell (MSC)/CB mononuclear cell ex vivo co-culture expansion system. |
| doi_str_mv | 10.1016/j.beha.2010.11.001 |
| format | Article |
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The ethnic diversity, relative ease of collection, ready availability as cryopreserved units from CB banks, reduced incidence and severity of graft versus host disease and tolerance of higher degrees of HLA disparity between donor and recipient, are positive attributes when compared to bone marrow or cytokine-mobilized peripheral blood. However, CB transplantation is associated with significantly delayed neutrophil and platelet engraftment and an elevated risk of graft failure. These hurdles are thought to be due, at least in part, to low total nucleated cell and CD34+ cell doses transplanted. 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All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-aed1d1c7d77ba582314f06ce699a00e4d00cfaa71554e0a47ba55b8cfd7496143</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1521692610001301$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21396596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Robinson, Simon N., Ph.D</creatorcontrib><creatorcontrib>Simmons, Paul J., Ph.D</creatorcontrib><creatorcontrib>Yang, Hong, Ph.D., MD</creatorcontrib><creatorcontrib>Alousi, Amin M., MD</creatorcontrib><creatorcontrib>Marcos de Lima, J., MD</creatorcontrib><creatorcontrib>Shpall, Elizabeth J., MD</creatorcontrib><title>Mesenchymal stem cells in ex vivo cord blood expansion</title><title>Best practice & research. 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Here, current strategies directed at improving TNC and CD34+ cell doses at transplant are discussed, with particular attention paid to the use of a mesenchymal stem cell (MSC)/CB mononuclear cell ex vivo co-culture expansion system.</description><subject>Adult</subject><subject>Antigens, CD34</subject><subject>Cell Adhesion</subject><subject>Cell Proliferation</subject><subject>Cell Separation - methods</subject><subject>Child</subject><subject>Coculture Techniques</subject><subject>cord blood (CB) transplantation</subject><subject>Cord Blood Stem Cell Transplantation</subject><subject>ex vivo expansion</subject><subject>Fetal Blood - cytology</subject><subject>Graft Survival</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>mesenchymal stem cells (MSC)</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Plastics</subject><issn>1521-6926</issn><issn>1532-1924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGLFDEQhRtR3HX1D3iQvnnqMZV00tMgC7Kou7DiQT0X6aTaydidjEnPsPPvTZh1UQ9CIKHy3qvkq6p6CWwFDNSb7WqgjV5xVgqwYgweVecgBW-g5-3jcubQqJ6rs-pZSlvGhOi5eFqdcRC9kr06r9QnSuTN5jjrqU4LzbWhaUq18zXd1Qd3CLUJ0dbDFILNpZ32yQX_vHoy6inRi_v9ovr24f3Xq-vm9vPHm6t3t42RrF8aTRYsmM523aDlmgtoR6YMqb7XjFFrGTOj1h1I2RLTbVHJYW1G27W9glZcVJen3N1-mMka8kvUE-6im3U8YtAO_77xboPfwwHFmkmheA54fR8Qw889pQVnl8oXtaewT7iWHYhMrstKflKaGFKKND50AYaFN26x8MbCGwEwu7Lp1Z_ve7D8BpwFb08CypQOjiIm4zJwsi6SWdAG9__8y3_sZnLeGT39oCOlbdhHn_kjYOLI8EuZeBk4sOLO6xfi-aZy</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Robinson, Simon N., Ph.D</creator><creator>Simmons, Paul J., Ph.D</creator><creator>Yang, Hong, Ph.D., MD</creator><creator>Alousi, Amin M., MD</creator><creator>Marcos de Lima, J., MD</creator><creator>Shpall, Elizabeth J., MD</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110301</creationdate><title>Mesenchymal stem cells in ex vivo cord blood expansion</title><author>Robinson, Simon N., Ph.D ; Simmons, Paul J., Ph.D ; Yang, Hong, Ph.D., MD ; Alousi, Amin M., MD ; Marcos de Lima, J., MD ; Shpall, Elizabeth J., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-aed1d1c7d77ba582314f06ce699a00e4d00cfaa71554e0a47ba55b8cfd7496143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Antigens, CD34</topic><topic>Cell Adhesion</topic><topic>Cell Proliferation</topic><topic>Cell Separation - methods</topic><topic>Child</topic><topic>Coculture Techniques</topic><topic>cord blood (CB) transplantation</topic><topic>Cord Blood Stem Cell Transplantation</topic><topic>ex vivo expansion</topic><topic>Fetal Blood - cytology</topic><topic>Graft Survival</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>mesenchymal stem cells (MSC)</topic><topic>Mesenchymal Stromal Cells - cytology</topic><topic>Plastics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Robinson, Simon N., Ph.D</creatorcontrib><creatorcontrib>Simmons, Paul J., Ph.D</creatorcontrib><creatorcontrib>Yang, Hong, Ph.D., MD</creatorcontrib><creatorcontrib>Alousi, Amin M., MD</creatorcontrib><creatorcontrib>Marcos de Lima, J., MD</creatorcontrib><creatorcontrib>Shpall, Elizabeth J., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Best practice & research. 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| ispartof | Best practice & research. Clinical haematology, 2011-03, Vol.24 (1), p.83-92 |
| issn | 1521-6926 1532-1924 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Antigens, CD34 Cell Adhesion Cell Proliferation Cell Separation - methods Child Coculture Techniques cord blood (CB) transplantation Cord Blood Stem Cell Transplantation ex vivo expansion Fetal Blood - cytology Graft Survival Hematology, Oncology and Palliative Medicine Humans mesenchymal stem cells (MSC) Mesenchymal Stromal Cells - cytology Plastics |
| title | Mesenchymal stem cells in ex vivo cord blood expansion |
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