Cord-Blood Engraftment with Ex Vivo Mesenchymal-Cell Coculture
Use of 2 units of cord blood, 1 of which had been cocultured with mesenchymal stem cells, produced more rapid hematopoietic engraftment than 2 units of unmanipulated cord blood. Umbilical-cord blood is an attractive source of hematopoietic support for patients who lack a suitable HLA-matched donor....
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| Veröffentlicht in: | The New England journal of medicine 2012-12, Vol.367 (24), p.2305-2315 |
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| container_title | The New England journal of medicine |
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| creator | de Lima, Marcos McNiece, Ian Robinson, Simon N Munsell, Mark Eapen, Mary Horowitz, Mary Alousi, Amin Saliba, Rima McMannis, John D Kaur, Indreshpal Kebriaei, Partow Parmar, Simrit Popat, Uday Hosing, Chitra Champlin, Richard Bollard, Catherine Molldrem, Jeffrey J Jones, Roy B Nieto, Yago Andersson, Borje S Shah, Nina Oran, Betul Cooper, Laurence J.N Worth, Laura Qazilbash, Muzaffar H Korbling, Martin Rondon, Gabriela Ciurea, Stefan Bosque, Doyle Maewal, Ila Simmons, Paul J Shpall, Elizabeth J |
| description | Use of 2 units of cord blood, 1 of which had been cocultured with mesenchymal stem cells, produced more rapid hematopoietic engraftment than 2 units of unmanipulated cord blood.
Umbilical-cord blood is an attractive source of hematopoietic support for patients who lack a suitable HLA-matched donor. Despite the advantages offered by cord-blood transplantation, such as the use of a frozen, readily available allograft in patients who are members of minority groups, who often have limited access to adult donors, the clinical usefulness in adults has been restricted by the relatively low number of hematopoietic progenitors in a unit of cord blood.
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Delayed or failed engraftment of neutrophils and platelets with cord-blood transplantation can result in an increased risk of transplant-related complications or death and increased health care costs, . . . |
| doi_str_mv | 10.1056/NEJMoa1207285 |
| format | Article |
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Umbilical-cord blood is an attractive source of hematopoietic support for patients who lack a suitable HLA-matched donor. Despite the advantages offered by cord-blood transplantation, such as the use of a frozen, readily available allograft in patients who are members of minority groups, who often have limited access to adult donors, the clinical usefulness in adults has been restricted by the relatively low number of hematopoietic progenitors in a unit of cord blood.
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Delayed or failed engraftment of neutrophils and platelets with cord-blood transplantation can result in an increased risk of transplant-related complications or death and increased health care costs, . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1207285</identifier><identifier>PMID: 23234514</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Waltham, MA: Massachusetts Medical Society</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Blood Cell Count ; Blood Platelets ; Bone marrow ; Cause of Death ; Cell Culture Techniques ; Cord Blood Stem Cell Transplantation ; General aspects ; Good Manufacturing Practice ; Graft Enhancement, Immunologic ; Graft vs Host Disease ; Hematologic Neoplasms - mortality ; Hematologic Neoplasms - therapy ; Humans ; Medical sciences ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stromal Cells ; Middle Aged ; Neutrophils ; Stem cells ; Transplantation Chimera ; Transplantation, Homologous ; Transplants & implants ; Young Adult</subject><ispartof>The New England journal of medicine, 2012-12, Vol.367 (24), p.2305-2315</ispartof><rights>Copyright © 2012 Massachusetts Medical Society. All rights reserved.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Massachusetts Medical Society. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c563t-711a2181a858454425e25826b741f30cf1f5a2b78dc2494765a195a4457be2943</citedby><cites>FETCH-LOGICAL-c563t-711a2181a858454425e25826b741f30cf1f5a2b78dc2494765a195a4457be2943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1207285$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1207285$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>230,314,776,780,881,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26727122$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23234514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Lima, Marcos</creatorcontrib><creatorcontrib>McNiece, Ian</creatorcontrib><creatorcontrib>Robinson, Simon N</creatorcontrib><creatorcontrib>Munsell, Mark</creatorcontrib><creatorcontrib>Eapen, Mary</creatorcontrib><creatorcontrib>Horowitz, Mary</creatorcontrib><creatorcontrib>Alousi, Amin</creatorcontrib><creatorcontrib>Saliba, Rima</creatorcontrib><creatorcontrib>McMannis, John D</creatorcontrib><creatorcontrib>Kaur, Indreshpal</creatorcontrib><creatorcontrib>Kebriaei, Partow</creatorcontrib><creatorcontrib>Parmar, Simrit</creatorcontrib><creatorcontrib>Popat, Uday</creatorcontrib><creatorcontrib>Hosing, Chitra</creatorcontrib><creatorcontrib>Champlin, Richard</creatorcontrib><creatorcontrib>Bollard, Catherine</creatorcontrib><creatorcontrib>Molldrem, Jeffrey J</creatorcontrib><creatorcontrib>Jones, Roy B</creatorcontrib><creatorcontrib>Nieto, Yago</creatorcontrib><creatorcontrib>Andersson, Borje S</creatorcontrib><creatorcontrib>Shah, Nina</creatorcontrib><creatorcontrib>Oran, Betul</creatorcontrib><creatorcontrib>Cooper, Laurence J.N</creatorcontrib><creatorcontrib>Worth, Laura</creatorcontrib><creatorcontrib>Qazilbash, Muzaffar H</creatorcontrib><creatorcontrib>Korbling, Martin</creatorcontrib><creatorcontrib>Rondon, Gabriela</creatorcontrib><creatorcontrib>Ciurea, Stefan</creatorcontrib><creatorcontrib>Bosque, Doyle</creatorcontrib><creatorcontrib>Maewal, Ila</creatorcontrib><creatorcontrib>Simmons, Paul J</creatorcontrib><creatorcontrib>Shpall, Elizabeth J</creatorcontrib><title>Cord-Blood Engraftment with Ex Vivo Mesenchymal-Cell Coculture</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Use of 2 units of cord blood, 1 of which had been cocultured with mesenchymal stem cells, produced more rapid hematopoietic engraftment than 2 units of unmanipulated cord blood.
Umbilical-cord blood is an attractive source of hematopoietic support for patients who lack a suitable HLA-matched donor. Despite the advantages offered by cord-blood transplantation, such as the use of a frozen, readily available allograft in patients who are members of minority groups, who often have limited access to adult donors, the clinical usefulness in adults has been restricted by the relatively low number of hematopoietic progenitors in a unit of cord blood.
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Delayed or failed engraftment of neutrophils and platelets with cord-blood transplantation can result in an increased risk of transplant-related complications or death and increased health care costs, . . .</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Cell Count</subject><subject>Blood Platelets</subject><subject>Bone marrow</subject><subject>Cause of Death</subject><subject>Cell Culture Techniques</subject><subject>Cord Blood Stem Cell Transplantation</subject><subject>General aspects</subject><subject>Good Manufacturing Practice</subject><subject>Graft Enhancement, Immunologic</subject><subject>Graft vs Host Disease</subject><subject>Hematologic Neoplasms - mortality</subject><subject>Hematologic Neoplasms - therapy</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mesenchymal Stem Cell Transplantation</subject><subject>Mesenchymal Stromal Cells</subject><subject>Middle Aged</subject><subject>Neutrophils</subject><subject>Stem cells</subject><subject>Transplantation Chimera</subject><subject>Transplantation, Homologous</subject><subject>Transplants & implants</subject><subject>Young 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J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cord-Blood Engraftment with Ex Vivo Mesenchymal-Cell Coculture</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2012-12-13</date><risdate>2012</risdate><volume>367</volume><issue>24</issue><spage>2305</spage><epage>2315</epage><pages>2305-2315</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Use of 2 units of cord blood, 1 of which had been cocultured with mesenchymal stem cells, produced more rapid hematopoietic engraftment than 2 units of unmanipulated cord blood.
Umbilical-cord blood is an attractive source of hematopoietic support for patients who lack a suitable HLA-matched donor. Despite the advantages offered by cord-blood transplantation, such as the use of a frozen, readily available allograft in patients who are members of minority groups, who often have limited access to adult donors, the clinical usefulness in adults has been restricted by the relatively low number of hematopoietic progenitors in a unit of cord blood.
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Delayed or failed engraftment of neutrophils and platelets with cord-blood transplantation can result in an increased risk of transplant-related complications or death and increased health care costs, . . .</abstract><cop>Waltham, MA</cop><pub>Massachusetts Medical Society</pub><pmid>23234514</pmid><doi>10.1056/NEJMoa1207285</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine Current |
| subjects | Adolescent Adult Biological and medical sciences Blood Cell Count Blood Platelets Bone marrow Cause of Death Cell Culture Techniques Cord Blood Stem Cell Transplantation General aspects Good Manufacturing Practice Graft Enhancement, Immunologic Graft vs Host Disease Hematologic Neoplasms - mortality Hematologic Neoplasms - therapy Humans Medical sciences Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells Middle Aged Neutrophils Stem cells Transplantation Chimera Transplantation, Homologous Transplants & implants Young Adult |
| title | Cord-Blood Engraftment with Ex Vivo Mesenchymal-Cell Coculture |
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