Origin and evolution of the adaptive immune system: genetic events and selective pressures

Key Points The adaptive immune system as defined in humans — which includes antigen receptors generated by recombination-activating gene (RAG)-mediated rearrangement and diversified by members of the AID-APOBEC family; the major histocompatibility (MHC); extensive chemokine and cytokine networks; an...

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Veröffentlicht in:	Nature reviews. Genetics 2010-01, Vol.11 (1), p.47-59
Hauptverfasser:	Flajnik, Martin F., Kasahara, Masanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Agriculture Animal Genetics and Genomics Animals Antigens Big Bang theory Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Lineage Cell receptors Enzymes Fishes Fundamental and applied biological sciences. Psychology Gene Function Genes Genetic aspects Genetic regulation Genetics of eukaryotes. Biological and molecular evolution Genomes Health aspects Human Genetics Humans Immune response Immune system Immune System - physiology Immunity - genetics Immunoglobulins Immunoglobulins - genetics Lymphocyte receptors Lymphocytes - immunology Major histocompatibility complex Major Histocompatibility Complex - genetics Marine Models, Genetic Physiological aspects Receptors, Antigen, B-Cell - immunology Receptors, Antigen, T-Cell - immunology Recombination, Genetic review-article Selection, Genetic T cell receptors Vertebrates Vertebrates - genetics
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