Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease

Mice with homozygous null mutations in the HDL receptor (scavenger receptor class B, type I, or SR-BI) and apolipoprotein E (apoE) genes [SR-BI/apoE double KO (SR-BI ⁻/⁻/apoE ⁻/⁻ or dKO) mice] spontaneously develop occlusive, atherosclerotic coronary artery disease (CAD) and die prematurely (50% mor...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-10, Vol.110 (42), p.17023-17028
Hauptverfasser:	Tsukamoto, Kosuke, Mani, D. R., Shi, Jianru, Zhang, Songwen, Haagensen, Darrow E., Otsuka, Fumiyuki, Guan, Jian, Smith, Jonathan D., Weng, Wei, Liao, Ronglih, Kolodgie, Frank D., Virmani, Renu, Krieger, Monty
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Animals Antioxidants Antioxidants - metabolism Apolipoproteins Apolipoproteins D - blood Apolipoproteins D - genetics Apolipoproteins E - genetics Apolipoproteins E - metabolism Atherosclerosis Biological Sciences Cardiovascular agents Cardiovascular disease Cell Hypoxia - genetics Cells, Cultured Coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - genetics Coronary Artery Disease - metabolism Coronary Artery Disease - pathology Disease Models, Animal Female Gene expression Heart Humans Ischemia Mice Mice, Knockout Mutation Myocardial Infarction - blood Myocardial Infarction - genetics Myocardial Infarction - pathology Myocardial Reperfusion Injury - blood Myocardial Reperfusion Injury - genetics Myocardial Reperfusion Injury - pathology Myocardium Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Oxidation Rats, Wistar Rodents Scavenger Receptors, Class B - genetics Scavenger Receptors, Class B - metabolism
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