Kisspeptin, Neurokinin B, and Dynorphin Act in the Arcuate Nucleus to Control Activity of the GnRH Pulse Generator in Ewes

Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin driving GnRH release and neurokinin B (NKB) and dynorphin acting as start and stop signals, respectively. In this study, we tes...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Endocrinology (Philadelphia) 2013-11, Vol.154 (11), p.4259-4269
Hauptverfasser:	Goodman, Robert L, Hileman, Stanley M, Nestor, Casey C, Porter, Katrina L, Connors, John M, Hardy, Steve L, Millar, Robert P, Cernea, Maria, Coolen, Lique M, Lehman, Michael N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arcuate nucleus Arcuate Nucleus of Hypothalamus - cytology Arcuate Nucleus of Hypothalamus - physiology Biological and medical sciences Dynorphin Dynorphins - genetics Dynorphins - metabolism Female Fundamental and applied biological sciences. Psychology Glutamate receptors Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone - genetics Gonadotropin-Releasing Hormone - metabolism Hypotheses Kiss1 protein Kisspeptins - genetics Kisspeptins - metabolism N-Methyl-D-aspartic acid receptors N-Methylaspartate - genetics N-Methylaspartate - metabolism Neural networks Neuroendocrinology Neurogenesis Neurokinin Neurokinin B Neurokinin B - genetics Neurokinin B - metabolism Neurons Neurons - classification Neurons - metabolism Neuropeptides Ovariectomy Pulse generators Receptors Receptors, Neurokinin-3 - genetics Receptors, Neurokinin-3 - metabolism Receptors, Opioid, kappa - genetics Receptors, Opioid, kappa - metabolism Secretion Sensory neurons Sheep - physiology Signal generation Vertebrates: endocrinology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!