Broadly Applicable Methodology for the Rapid and Dosable Small Molecule-Mediated Regulation of Transcription Factors in Human Cells

Direct and selective small molecule control of transcription factor activity is an appealing avenue for elucidating the cell biology mediated by transcriptional programs. However, pharmacologic tools to modulate transcription factor activity are scarce because transcription factors are not readily a...

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Veröffentlicht in:	Journal of the American Chemical Society 2013-06, Vol.135 (22), p.8129-8132
Hauptverfasser:	Shoulders, Matthew D, Ryno, Lisa M, Cooley, Christina B, Kelly, Jeffery W, Wiseman, R. Luke
Format:	Artikel
Sprache:	eng
Schlagworte:	cell biology DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Heat Shock Transcription Factors HEK293 Cells Humans Molecular Structure protein degradation Tacrolimus Binding Protein 1A - metabolism transcription (genetics) transcription factors Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription Factors - metabolism transcriptional activation
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