Radiosynthesis of PET radiotracer as a prodrug for imaging group II metabotropic glutamate receptors in vivo

Group II metabotropic glutamate receptors (mGluRs) have been implicated in a variety of neurological and psychiatric disorders in recent studies. As a noninvasive medical imaging technique and a powerful tool in neurological research, positron emission tomography (PET) offers the possibility to visu...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-03, Vol.22 (5), p.1958-1962
Hauptverfasser:	Wang, Ji-Quan, Zhang, Zhaoda, Kuruppu, Darshini, Brownell, Anna-Liisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - pharmacology Animals Biological and medical sciences Brain - diagnostic imaging Brain - metabolism Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism glutamic acid Group II mGluRs hippocampus Hippocampus - diagnostic imaging Hippocampus - metabolism image analysis Male Medical sciences mGluR2 mGluR3 PET Pharmacology. Drug treatments positron-emission tomography Positron-Emission Tomography - methods Prodrug Prodrugs - chemical synthesis Prodrugs - pharmacokinetics Protein Binding - drug effects Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - pharmacokinetics Rats Rats, Sprague-Dawley receptors Receptors, Metabotropic Glutamate - analysis Xanthenes - pharmacology
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