The SAR analysis of TRPV1 agonists with the α-methylated B-region

A series of TRPV1 agonists with amide, reverse amide, and thiourea groups in the B-region and their corresponding α-methylated analogues were investigated. Whereas the α-methylation of the amide B-region enhanced the binding affinities and potencies as agonists, that of the reverse amide and thioure...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2012-08, Vol.22 (16), p.5227-5231
Hauptverfasser: Cho, Yongsung, Kim, Myeong Seop, Kim, Ho Shin, Ann, Jihyae, Lee, Jiyoun, Pearce, Larry V., Pavlyukovets, Vladimir A., Morgan, Matthew A., Blumberg, Peter M., Lee, Jeewoo
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Sprache:eng
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