ASIC1a-Specific Modulation of Acid-Sensing Ion Channels in Mouse Cortical Neurons by Redox Reagents

Acid-sensing ion channel (ASIC)-1a, the major ASIC subunit with Ca2+ permeability, is highly expressed in the neurons of CNS. Activation of these channels with resultant intracellular Ca2+ accumulation plays a critical role in normal synaptic plasticity, learning/memory, and in acidosis-mediated glu...

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Veröffentlicht in:	The Journal of neuroscience 2006-05, Vol.26 (20), p.5329-5339
Hauptverfasser:	Chu, Xiang-Ping, Close, Natasha, Saugstad, Julie A, Xiong, Zhi-Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Sensing Ion Channels Amino Acid Sequence - physiology Animals Calcium - metabolism Calcium Signaling - drug effects Calcium Signaling - physiology Cells, Cultured Cerebral Cortex - drug effects Cerebral Cortex - metabolism CHO Cells Cricetinae Cysteine - chemistry Extracellular Fluid - chemistry Lysine - chemistry Membrane Potentials - drug effects Membrane Potentials - physiology Membrane Proteins - drug effects Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout Nerve Tissue Proteins - drug effects Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons - drug effects Neurons - metabolism Oxidants - pharmacology Oxidation-Reduction - drug effects Patch-Clamp Techniques Protein Structure, Tertiary - physiology Reducing Agents - pharmacology Sodium Channels - drug effects Sodium Channels - genetics Sodium Channels - metabolism
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