1,25(OH)₂D₃-enhanced hypercalciuria in genetic hypercalciuric stone-forming rats fed a low-calcium diet

The inbred genetic hypercalciuric stone-forming (GHS) rats exhibit many features of human idiopathic hypercalciuria and have elevated levels of vitamin D receptors (VDR) in calcium (Ca)-transporting organs. On a normal-Ca diet, 1,25(OH)2D3 (1,25D) increases urine (U) Ca to a greater extent in GHS th...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2013-10, Vol.305 (8), p.F1132-F1138
Hauptverfasser:	Frick, Kevin K, Asplin, John R, Krieger, Nancy S, Culbertson, Christopher D, Asplin, Daniel M, Bushinsky, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcitriol - administration & dosage Calcium - administration & dosage Calcium - urine Calcium, Dietary - administration & dosage Disease Models, Animal Hypercalcemia - congenital Hypercalcemia - genetics Hypercalcemia - metabolism Hypercalciuria - chemically induced Hypercalciuria - metabolism Intestinal Absorption - physiology Kidney Calculi - genetics Kidney Calculi - metabolism Male Rats Rats, Sprague-Dawley Receptors, Calcitriol - metabolism
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