Transforming growth factor-β1 impairs CFTR-mediated anion secretion across cultured porcine vas deferens epithelial monolayer via the p38 MAPK pathway

The goal of this study was to determine whether transforming growth factor-β1 (TGF-β1) affects epithelial cells lining the vas deferens, an organ that is universally affected in cystic fibrosis male patients. In PVD9902 cells, which are derived from porcine vas deferens epithelium, TGF-β1 exposure s...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2013-10, Vol.305 (8), p.C867-C876
Hauptverfasser:	Yi, Sheng, Pierucci-Alves, Fernando, Schultz, Bruce D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anions - metabolism Anisomycin - pharmacology Benzamides - pharmacology Cells, Cultured Cystic Fibrosis - metabolism Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Dioxoles - pharmacology Enzyme Inhibitors - pharmacology Epithelial Cells - metabolism Imidazoles - pharmacology Infertility, Male - metabolism Male MAP Kinase Signaling System - drug effects p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Protein Synthesis Inhibitors - pharmacology Pyridines - pharmacology RNA, Messenger - genetics RNA, Messenger - metabolism Swine Transforming Growth Factor beta1 - antagonists & inhibitors Transforming Growth Factor beta1 - metabolism Vas Deferens - metabolism
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