CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis

The objective of this study was to elucidate the signaling pathway through which cationic antimicrobial protein of 37 kDa (CAP37) mediates human corneal epithelial cell (HCEC) chemotaxis. Immortalized HCECs were treated with pertussis toxin (10 and 1000 ng/mL), protein kinase C (PKC) inhibitors (cal...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2013-10, Vol.54 (10), p.6712-6723
Hauptverfasser:	Griffith, Gina L, Russell, Robert A, Kasus-Jacobi, Anne, Thavathiru, Elangovan, Gonzalez, Melva L, Logan, Sreemathi, Pereira, H Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial Cationic Peptides - metabolism Blood Proteins - metabolism Blotting, Western Carrier Proteins - metabolism Cells, Cultured Chemotaxis - physiology Enzyme Activation Epithelium, Corneal - cytology Epithelium, Corneal - metabolism Glycoproteins Humans Immunohistochemistry Microscopy, Confocal Protein Kinase C - metabolism Signal Transduction
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