Bioluminescent detection of peroxynitrite with a boronic acid-caged luciferin

Peroxynitrite, a highly reactive biological oxidant, is formed under pathophysiologic conditions from the diffusion-limited reaction of nitric oxide and superoxide radical anion. Peroxynitrite has been implicated as the mediator of nitric oxide toxicity in many diseases and as an important signaling...

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Veröffentlicht in:	Free radical biology & medicine 2013-08, Vol.61, p.40-50
Hauptverfasser:	Sieracki, Nathan A., Gantner, Benjamin N., Mao, Mao, Horner, John H., Ye, Richard D., Malik, Asrar B., Newcomb, Martin E., Bonini, Marcelo G.
Format:	Artikel
Sprache:	eng
Schlagworte:	albumins Animals Benzothiazoles - metabolism bioluminescence biosensors Boronate Boronic Acids carbon dioxide catalase detection limit endotoxins Free radicals glutathione hydrogen peroxide in vivo studies lipopolysaccharides Luciferin Luminescent Measurements - methods macrophages mammals Mice nitric oxide Nitric Oxide Synthase Type II - physiology oxidants PCL-1 Peroxynitrite Peroxynitrous Acid - analysis Peroxynitrous Acid - blood Sensor superoxide anion toxicity
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